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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard OECD test guidelines
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.26
Temp.:
25 °C
pH:
7.6
Remarks on result:
other: logKow was reported to be 2.260 ± 0.001
Details on results:
The Partition coefficient (Pow) of the test chemical was determined to be 2.260 ± 0.001 at 25°C.

Test substance

K

Log k

Log Pow

by Generalized Calibration

Graph

Mean of Log Pow ± S.D.

tR1

1.724

0.918

-0.037

2.259

2.260 ± 0.001

tR2

1.725

0.920

-0.036

2.260

Conclusions:
The partition coefficient(n-octanol/water) of test chemical was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 2.260 ± 0.001 at 25°C.
Executive summary:

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately measuring 4 micro liter of test chemical and diluted with methanol up to 10 ml. Thus, the test solution concentration was 367.2 mg/l. The pH of test substance was 7.6. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were 4 -Acetylpyridine, Acetophenone, Benzophenone, 4-Methoxyphenol, Phenol, Benzene, Biphenyl, Methyl benzoate, Benzyl Benzoate, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, 2,6-Diphenylpyridine, Bromobenzene, 2,3-Dichloroaniline, Triphenylamine, Acetanilide, 2-Nitrophenol, Nitrobenzene, 2,6 -Dichlorobenzonitrile, Diphenylamine, Cinnamyl alcohol, Benzyl alcohol, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene, Diphenyl ether, Allyl phenyl ether, DDT having Pow value ranging from 0.5 to 6.5. The Log Pow value of the test chemical was determined to be 2.260 ± 0.001 at 25°C. On the basis of this value, test chemical is considered to be hydrophilic.

Description of key information

Based on the available data from study report,the partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately measuring 4 micro liter of test chemical and diluted with methanol up to 10 ml. Thus, the test solution concentration was 367.2 mg/l. The pH of test substance was 7.6. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were 4 -Acetylpyridine, Acetophenone, Benzophenone, 4-Methoxyphenol, Phenol, Benzene, Biphenyl, Methyl benzoate, Benzyl Benzoate, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, 2,6-Diphenylpyridine, Bromobenzene, 2,3-Dichloroaniline, Triphenylamine, Acetanilide, 2-Nitrophenol, Nitrobenzene, 2,6 -Dichlorobenzonitrile, Diphenylamine, Cinnamyl alcohol, Benzyl alcohol, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene, Diphenyl ether, Allyl phenyl ether, DDT having Pow value ranging from 0.5 to 6.5. The Log Pow value of the test chemical was determined to be 2.260 ± 0.001 at 25°C. On the basis of this value, test chemical is considered to be hydrophilic.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.26
at the temperature of:
25 °C

Additional information

Based on the available data from study report,the partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test chemical solution was prepared by accurately measuring 4 micro liter of test chemical and diluted with methanol up to 10 ml. Thus, the test solution concentration was 367.2 mg/l. The pH of test substance was 7.6. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were 4 -Acetylpyridine, Acetophenone, Benzophenone, 4-Methoxyphenol, Phenol, Benzene, Biphenyl, Methyl benzoate, Benzyl Benzoate, 1,4-Dichlorobenzene, 1,2,4-Trichlorobenzene, 2,6-Diphenylpyridine, Bromobenzene, 2,3-Dichloroaniline, Triphenylamine, Acetanilide, 2-Nitrophenol, Nitrobenzene, 2,6 -Dichlorobenzonitrile, Diphenylamine, Cinnamyl alcohol, Benzyl alcohol, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene, Diphenyl ether, Allyl phenyl ether, DDT having Pow value ranging from 0.5 to 6.5. The Log Pow value of the test chemical was determined to be 2.260 ± 0.001 at 25°C. On the basis of this value, test chemical is considered to be hydrophilic.