Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: (i) no information on housing and feeding conditions given, (ii) no pathology reporting, (iii) no information on test substance stability, batch and purity given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report Date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other:
Doses:
5000 mg/kg bw.
No. of animals per sex per dose:
10 animals
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Statistics:
not needed

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
0
Clinical signs:
slightly lethargy
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 > 5000 mg/kg bw
According to Directive 67/548/EEC and its subsequent amendments, 4-(4-Methyl-pent-3-enyl)-cyclohex-3-enecarbaldehyde should not be classified as acute oral toxic.
According to the Regulation (EC) No 1272/2008 and subsequent regulations, 4-(4-Methyl-pent-3-enyl)-cyclohex-3-enecarbaldehyde should not be classified as acute oral toxic.