Registration Dossier
Registration Dossier
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EC number: 221-304-1 | CAS number: 3061-75-4
Endpoint summary
Administrative data
Description of key information
Additional information
The hazard assessment is based on the data currently available. This information will be submitted later based on ECHA communication/decision number TPE/CCH-D-2114598209-34-01/F.
No data are available on the toxicity of docosanamide (CAS No. 3061-75-4) to fish, daphnia and algae.
Short term tests with species of 3 trophic levels are available for the structural related substance amides, C16-C18 (even numbered) and based on this tests, the test substance can be regarded as acutely not harmful to aquatic organisms. Short term toxicity data of the substance towards fish, daphnia and algae give a NOEC greater than the water solubility of amides, C16-18 (even numbered). No toxicity could be observed in any test.
Additionally, long term test with the structural related (Z)-Docos-13-enamide was conducted. (Z)-Docos-13-enamide (CAS 112-84-5), is the fatty acid amide resulting from the amidation of erucic acid. Erucic acid is a mono-unsaturated fatty acid with a carbon chain consisting of 22 carbon atoms with a double bond at position 13 (omega-9) of the carbon chain (cis-docos-13-enoic acid) and is therefore structural related to the registered substance which have the same functional groups and metabolic pathway.
Both fatty acids are abundantly available in our daily nutrition and are utilised by fat metabolism. It is therefore considered valid to read-across the results for (Z)-Docos-13-enamide to fill the data gap for the registered substance.
The available study report on long-term toxicity of (Z)-Docos-13-enamide to fish conducted according to OECD 215 demonstrate no effect up to the limit of the water solubility of the tested substance. The same applies for a long term daphnia study according to OECD 202 for (Z)-Docos-13-enamide, detecting no effects up to the limit of the water solubility of the tested substance. Furthermore the inhibition of the degradation activity of activated sludge is not anticipated.
Thus, docosanamide (CAS No. 3061-75-4) can be regarded as not harmful for aquatic organisms.
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