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Diss Factsheets
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EC number: 274-713-2 | CAS number: 70643-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- A readacross with the analogue substance 2-(2,4-diaminophenoxy)ethanol dihydrochloride is proposed. The substance detailed in section 1 and the analogue material are both salts of 2-(2,4-diaminophenoxy)ethanol with similar physical and chemical properties.
Data source
Referenceopen allclose all
- Reference Type:
- other: Published secondary source
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- other: Single dose acute toxicity study
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(2,4-diaminophenoxy)ethanol dihydrochloride
- EC Number:
- 266-357-1
- EC Name:
- 2-(2,4-diaminophenoxy)ethanol dihydrochloride
- Cas Number:
- 66422-95-5
- Molecular formula:
- C8H12N2O2.2ClH
- IUPAC Name:
- 2-(2,4-diaminophenoxy)ethanol dihydrochloride
- Details on test material:
- Test item : Imexine OAJ 2952
EC number : 266-357-1
Batch number : 0101297
Purity : 99.6%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Credo, France
- Age at study initiation: ~6 weeks old
- Weight at study initiation: 195+/-3g for males and 156+/-6g for females
- Fasting period before study: ~18 hours before dosing
- Housing: Polycarbonate cages (48cm x 27cm x 20cm)
- Diet (e.g. ad libitum): All animals had free access to A04C pelleted diet (UAR, 91360 Villemoisson-sur-Orge, France)
- Water (e.g. ad libitum): Drinking water filtered by FG Millipore membrane (0.22 micron) was provided ad libitum
- Acclimation period: At least 5 days before the beginning of the study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21+/-2
- Humidity (%): 30-70
- Air changes (per hr): ~12
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: On day 15 (1998-07-09) all surviving animals were killed by carbondioxide asphyxiation
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10w/v%
- Amount of vehicle (if gavage): <10 ml/kg
- Justification for choice of vehicle: solubility
- Lot/batch no. (if required): 0101297 (test item)
- Purity: 99.6% (test item) - Doses:
- 1000 mg/kg bw
- No. of animals per sex per dose:
- One group of 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: 30min, 1, 2, 4, 6hours, days 2-15 (clinical signs); days 1, 8, 15 (weighing)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic examination of main organs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- A single dose of 1000 mg/kg bw induced death in 1/5 male and 3/5 female rats.
- Clinical signs:
- other: Hypoactivity or sedation and piloerection were noted in all animals on day 1. Lateral recumbency and tonic-clonic convulsions were also observed in two animals on day 1, one of these animals was found dead a few hours later. One male and two females were
- Gross pathology:
- No apparent abnormalities were observed at necropsy in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- For the purpose of REACH registration, read across with the analogue substance 2-(2,4-diaminophenoxy)ethanol dihydrochloride appears appropriate. Under the experimental conditions, the LD50 of the test item was close to 1000 mg/kg bw since a single dose of 1000 mg/kg induced death in 1/5 male and 3/5 female rats. Based on the available data for 2-(2,4-diaminophenoxy)ethanol dihydrochloride the acute oral toxicity of 2-(2,4-diaminophenoxy)ethanol sulphate is calculated to be 1104 mg/kg bw.
- Executive summary:
For the purpose of REACH registration, read across with the analogue substance 2-(2,4-diaminophenoxy)ethanol dihydrochloride appears appropriate. The acute oral toxicity of the substance was assessed according to OECD 401 incompliance to GLP. Under the experimental conditions, the LD50 of the test item was close to 1000 mg/kg bw. Based on the available data for 2-(2,4-diaminophenoxy)ethanol dihydrochloride the acute oral toxicity of 2-(2,4-diaminophenoxy)ethanol sulphate is calculated to be 1104 mg/kg bw. In accordance with Directive 67/548 and Regulation (EC) No 1272/2008 the substance is classified as harmful if swallowed.
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