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EC number: 265-004-9 | CAS number: 64665-57-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed and documented study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 4(or 5)-methyl-1H-benzotriazolide
- EC Number:
- 265-004-9
- EC Name:
- Sodium 4(or 5)-methyl-1H-benzotriazolide
- Cas Number:
- 64665-57-2
- Molecular formula:
- C7H7N3.Na
- IUPAC Name:
- sodium 4(or5)-methylbenzotriazol-1-ate
- Test material form:
- other: solution
- Details on test material:
- - Name of test material (as cited in study report): Preventol CI 7-50
- Substance type: organic
- Physical state: solution
- Composition of test material, percentage of components: 50 % aqueous solution
- Lot/batch No.: 150-5-45
- Storage condition of test material: tightly closed container
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sasco, Inc., Omaha, Nebraska
- Weight at study initiation: 229 to 391 g (male), 232 to 289 g (female)
- Fasting period before study: yes
- Housing: stainless steel cages, 5 animals per cage
- Diet: Purina laboratory rodent checkers
- Water: ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5 - 23.5
- Humidity (%): 35 - 55
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 362 - 1080 mg/kg bw
- Amount of vehicle (if gavage): 1 % of body weight - Doses:
- female: 362/434/521/625/685/750/822/900/1080 mg/kg
male: 362/434/521/625/750/822/900/1080 mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
observation: yes, nofrequency mentioned
weighing: on the day of treatment, on day 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 values were calculated by probit analysis using software from SAS Institute, Inc., Cary, North Carolina. Mortality data at each dose level was utilized in the calculation of the LD50 value and confidence interval.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 735 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 660 - < 832
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 930 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 831 - < 1 114
- Mortality:
- Mortality occurred in female rats at doses of 685 mg/kg or higher and in male rats at doses of 822 mg/kg or higher. The time of death was within 7 hours after application, only in the female group treated with 822 mg/kg bw death occured 23 hours after application
- Clinical signs:
- other: Clinical signs occurred in both sex at doses of 362 mg/kg or higher. Signs progressed from decreased physical activity at lower doses to ataxia at higher doses with lacrimation being observed prior to death. Additional signs observed in surviving animals,
- Gross pathology:
- Gross lesions observed in female animals found dead within the first 24 hours postadministration included:
white to tan nasal discharge, fluid-filled gastrointestinal tract, salivation, dark red or mottled lungs.
Incidental findings in female animals included:
ocular abnormality, dilated right renal pelvis and cannibalism.
Gross lesions observed in male animals found dead within the first 24 hours postadministration included:
fluid in the gastointestinal tract.
Incidental findings in male animals included:
dark red lungs, hyperemia of the gastric mucosa.
The surviving animals showed after 14 days no copound-related lesions.
Applicant's summary and conclusion
- Conclusions:
- The study is well performed and gives following results for the Endpoint:
The LD50 for the acute oral toxicity is 735 mg/kg bw (for female animals, for males a higher value and therefore less concerning value is found).
The NOEL is less than 362 mg/kg.
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