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EC number: 209-502-6 | CAS number: 583-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from J-CHECK, EnviChem and BCF authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances"
- Principles of method if other than guideline:
- Bioaccumulation study was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Carp
- Length at study initiation (lenght definition, mean, range and SD): 8
- Sex: MF - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
- Test temperature:
- 25°C
- pH:
- 6.0-8.5
- Details on test conditions:
- RANGE-FINDING / PRELIMINARY STUDY
- Test concentrations: TLm (48hr) 160 mg/l (160 ppm) (w/v), Rice fish (Oryzias latipes) - Nominal and measured concentrations:
- Nominal concentrations:
1st concentration area: 0.5 mg/l (0.5 ppm) (w/v)
2nd concentration area: 0.05 mg/l (0.05 ppm) (w/v) - Reference substance (positive control):
- not specified
- Conc. / dose:
- 0.5 mg/L
- Type:
- BCF
- Value:
- > 0.7 - < 3.5 L/kg
- Basis:
- whole body w.w.
- Time of plateau:
- 6 wk
- Remarks on result:
- other: Other details not known
- Conc. / dose:
- 0.05 mg/L
- Type:
- BCF
- Value:
- <= 2.6 L/kg
- Basis:
- whole body w.w.
- Time of plateau:
- 6 wk
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 0.7-3.5 L/Kg at a conc. of 0.5 mg/l and ≤ 2.6 L/Kg at a conc. of 0.05 mg/l, respectively.
- Executive summary:
Bioaccumulation study was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed according to other guideline"Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively under flow through conditions at a temperature of25°C and pH range 6.0-8.5, respectively. Cyprinus carpio(length - 8 dimensionless)was used as a test organism for the study.Test chemical nominal conc. used for the study were 0.5mg/l and 0.05 mg/l, respectively. Range finding study involve the TLm (48 hr) 160 mg/l (w/v) on Rice fish (Oryzias latipes). The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 0.7-3.5 L/Kg at a conc. of 0.5 mg/l and ≤ 2.6 L/Kg at a conc. of 0.05 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
Reference
Bioaccumulation test results:
|
2 W |
3 W |
4 W |
6 W |
|
1st Concentration area
|
Test substance concentration (ppm (w/v) |
0.37 |
0.38 |
0.40 |
0.43 |
Bioconcentration factor (L/kg) |
3.5 |
2.7 |
2.4 |
2.1 |
|
0.7 |
1.9 |
1.9 |
1.5 |
||
2nd Concentration area
|
Test substance concentration (ppm (w/v) |
0.045 |
0.047 |
0.048 |
0.050 |
Bioconcentration factor (L/kg) |
≤ 2.6 |
≤ 2.6 |
≤ 2.6 |
≤ 2.6 |
|
≤ 2.6 |
≤ 2.6 |
≤ 2.6 |
≤ 2.6 |
Description of key information
Bioaccumulation study was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical (authoritative database, 2018). The study was performed according to other guideline"Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively under flow through conditions at a temperature of25°C and pH range 6.0-8.5, respectively. Cyprinus carpio(length - 8 dimensionless)was used as a test organism for the study.Test chemical nominal conc. used for the study were 0.5mg/l and 0.05 mg/l, respectively. Range finding study involve the TLm (48 hr) 160 mg/l (w/v) on Rice fish (Oryzias latipes). The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 0.7-3.5 L/Kg at a conc. of 0.5 mg/l and ≤ 2.6 L/Kg at a conc. of 0.05 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.5 L/kg ww
Additional information
Experimental key study and various predicted data of the test chemical were reviewed for the bioaccumulation end point which are summarized as below:
In an experimental key study from authoritative databases (2018),bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively under flow through conditions at a temperature of25°C and pH range 6.0-8.5, respectively. Cyprinus carpio (length - 8 dimensionless)was used as a test organism for the study. Test chemical nominal conc. used for the study were 0.5mg/l and 0.05 mg/l, respectively. Range finding study involve the TLm (48 hr) 160 mg/l (w/v) on Rice fish (Oryzias latipes). The bioconcentration factor (BCF value) of test chemical on Cyprinus carpio was determined to be in the range of 0.7-3.5 L/Kg at a conc. of 0.5 mg/l and ≤ 2.6 L/Kg at a conc. of 0.05 mg/l, respectively.
In a prediction done using the BCFBAF Program of Estimation Programs Interface was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 5.785 L/kg whole body w.w (at 25 deg C).
Another predicted data was estimated using Bio-concentration Factor module (ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017)) for predicting the bioconcentration factor (BCF) of test chemical.The bio-concentration Factor of the test chemical was estimated to be 1 dimensionless at pH range 1-14, respectively.
On the basis of above results for test chemical, it can be concluded that the BCF value of test chemical was evaluated to beranges from0.7 to 5.785, respectively,which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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