Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 940-123-5 | CAS number: 866889-74-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The weighted n-octanol/water partition coefficients (log Kow) of C16-18 DMAPA amidoamine at pH 4, 7 and 9 are 2.00, 2.01 and 2.57, respectively (EU method A.8; estimated by calculation based on the solubility of the test substance in n-Octanol and water; read-across from Stearic acid 3-(dimethylaminopropyl)amide).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.01
- at the temperature of:
- 20 °C
Additional information
C16-18 DMAPA amidoamine is a UVCB substance with variable chain length of the fatty acid moiety. Thus, the partition coefficient (log P) can only be estimated for distinct structures. An estimation for the mixture cannot be given. For the estimation the ACD PhysChem software ACD/Labs Release 12.00, Product version 12.01 (Build 38056 09 Feb 2010) was used.
The calculated log P for the main constituents of C16-18 DMAPA amidoamine are summarised in the table below.
|
Log Pcalculated |
Hexadecanoic acid |
6.81 ± 0.19 |
Octadecanoic acid |
7.83 ± 0.19 |
N-(3-(dimethylamino)propyl)-hexadecanamide |
6.6 ± 0.3 |
N-(3-(dimethylamino)propyl)-octadecanamide |
7.62 ± 0.32 |
However, this calculation does not take into account, that the main constituents of the substance (N-(3-(dimethylamino)propyl)-hexadecanamide and N-(3-(dimethylamino)propyl)-octadecanamide) are mostly protonated at environmentally relevant pH.
Weighted log Kow values also considering protonation are available for one of the main constituents of C16-18 DMAPA amidoamine:
According to EU method A.8, 31 May 2008 the n-octanol/water partition coefficient (log Kow) of Stearic acid 3-(dimethylaminopropyl)amide was estimated by calculation based on the solubility of the test substance in n-Octanol and water.
solubility [g/L] |
log Kow |
||
n-octanol |
water |
||
free amine |
151 |
0.01 |
4.18 |
protonated amine |
22 |
0.22 |
2.04 |
Weighted log Kow were calculated taking into account the presence of the free and protonated amine at different pH values.
free amine [%] |
protonated amine [%] |
weighted log Kow |
|
pH 4 |
0 |
100 |
2.00 |
pH 7 |
0.4 |
99.6 |
2.01 |
pH 9 |
26.2 |
73.8 |
2.57 |
The weighted log Kow at pH 4, 7 and 9 are 2.00, 2.01 and 2.57, respectively.
For chemical safety assessment these values are considered to be more realistic than the QSAR-based log Kow for C16-18 DMAPA amidoamine.
The following results from a supporting substance (C22-alkyltrimethylammonium chloride) are enclosed for justification of read-across:
Since the substance is a quaternary alkyltrimethylammonium chloride, it exhibits surface active properties. In such a case, the experimental determination of the partition coefficient Kow is afflicted with errors. Therefore, the Kow will be presented as the comparison between the measured solubilities in both solvents water and n-octanol respectively. In case of water-solubility the value of the critical micelle concentration (cmc) was used as suggested.
n-Octanol solubility: 19.7 g/L
water solubility: 10 mg/L
log Kow = 3.29
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.