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Diss Factsheets
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EC number: 210-959-9 | CAS number: 626-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles. Acceptable with restrictions (limited documentation, only 2 animals used, 72-hrs reading missing, observation period only 8 days).
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
- Principles of method if other than guideline:
- Standardized test method (BASF-Test)
Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test). White Vienna rabbits were used. 2 animals were treated for 1, 5, 15 minutes using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the liquid test substance on a patch. After the application time of 1, 5, and 15 minutes, respectively, the skin was first washed with undiluted Lutrol 9, then with an aqueous Lutrol solution (50 %). The animals were observed for 8 days and skin reactions were recorded 24, 48 hours, 5 and 8 days after treatment. - GLP compliance:
- no
Test material
- Reference substance name:
- 1-methylpiperidine
- EC Number:
- 210-959-9
- EC Name:
- 1-methylpiperidine
- Cas Number:
- 626-67-5
- Molecular formula:
- C6H13N
- IUPAC Name:
- 1-methylpiperidine
- Details on test material:
- - Name of test material (as cited in study report): Methylpiperidine
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3.07 kg (female) and 3.81 kg (male)
ENVIRONMENTAL CONDITIONS
no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 1 min, 5 min, 15 min
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: no data
REMOVAL OF TEST SUBSTANCE
- Washing: yes (exposure 1, 5, 15 min) first with undiluted Lutrol 9, then with an aqueous Lutrol solution (50 %)
- Time after start of exposure: 1, 5, and 15 min, respectively
SCORING SYSTEM:
- Descriptive scores of the raw data have been converted to Draize numerical scores.
READINGS:
- 24 and 48 hours as well as 8 days after treatment.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Necrosis
- Remarks on result:
- other: ≥ 5 min exposure duration led to fullthickness necrosis observed after 24 hours.
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration: 1 min)
- Basis:
- mean
- Remarks:
- (animal #1 and #2)
- Time point:
- other: 24 and 48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis (parchment-like)
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration: 1 min)
- Basis:
- animal #1
- Time point:
- other: 24 and 48 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration: 1 min)
- Basis:
- animal #2
- Time point:
- other: 24 and 48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration: 5 min)
- Basis:
- mean
- Remarks:
- (animal #1 and #2)
- Time point:
- other: 24 and 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis (hard)
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration: 5 min)
- Basis:
- mean
- Remarks:
- (animal #1 and #2)
- Time point:
- other: 24 and 48 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Remarks:
- (exposure duration: 15 min)
- Basis:
- mean
- Remarks:
- (animal #1 and #2)
- Time point:
- other: 24 and 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Necrosis (hard)
- Irritation parameter:
- edema score
- Remarks:
- (exposure duration: 15 min)
- Basis:
- mean
- Remarks:
- (animal #1 and #2)
- Time point:
- other: 24 and 48 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- 1 min exposure:
bleedings at the application side; after 24 and 48 hours: moderate to strong redness (score 3); after 48 hours additionally slight edema (score 2); after 5 days moderate edema (score 3) and blotchy necrosis; at the end of the observation period parchment-like necrosis, not reversible.
5 min exposure:
red-brown parchment-like and leathery necrosis; after 24 and 48 hours red-brown hard necrosis with reddened edge (erythema score 2), after 5 days and at the end of the observation period hard, leathery necrosis, not reversible.
15 min exposure:
red-brown to grey-brown, leathery necrosis; after 24 and 48 hours hard necrosis with reddened edge (erythema score 3), after 5 days and at the end of the observation period hard necrosis, not reversible.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information
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