Registration Dossier
Registration Dossier
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EC number: 210-959-9 | CAS number: 626-67-5
Neurotoxicity
Administrative data
Description of key information
There are no valid in vivo data available for the assessment of neurotoxicity of the test item.
Key value for chemical safety assessment
Additional information
The effect of N-methylpiperidine was tested in 4 different neurologically relevant parameters: Local anaesthetic effect to an unnamed species; effect on the number and amplitude of stimuli on an unconditional reflex response in the CNS of rabbits; influence of the latent period of a conditional avoidance reflex in rats, shortening of hexobarbital sleeping time in mice.
No local anaesthetic effect, but a central stimulant action was demonstrated for 1-methylpiperidine. The unconditioned reflex reaction (referred to as "impulse summation" in CNS) was determined to be improved at the low dose tested (0.5 mg/kg bw), and impaired at higher doses (from 20 mg/kg bw). Additionlly, the latent period of avoidance reflex was shortened at the low dose investigated (1 mg/kg bw) and prolonged at the high dose (10 mg/kg bw). A shortening effect on hexobarbital (67 mg/kg bw) induced sleep by 16% was observed after treatment with 1-methylpiperidine
(6 mg/kg bw).
The study was not accessable (reliability 4) for assessment.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
There are no valid data available for neurotoxicity for the purpose of classification under Directive 67/548/EEC.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
There are no valid data available for neurotoxicity for the purpose of classification under Regulation (EC) No.1272/2008.
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