Registration Dossier
Registration Dossier
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EC number: 939-237-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The key study for oral toxicity reports an LD50 value of >5000mg/kg for MCS#10, (undecanol, linear and branched) (Biolab SGS, 1981; rel 2). The key study for inhalation toxicity was read across from undecan-1-ol (CAS 112-42-5), reporting an LC50 value of >700 mg/m3 air in rat (Younger Labs, 1972; rel 2).The key study for dermal toxicity is also read across from undecan-1-ol, and reports an LD50 value of >5010 - <7940mg/kg in rabbit (Younger Labs, 1977; rel 2).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
No information was available for the acute inhalation and dermal toxicity of MCS#10, undecanol, linear and monobranched alcohols C6 -C12. The data was therefore read across from 1-decanol (CAS 112 -3 0-1) (Scientific Associates Inc, 1977) and undecan-1 -ol (CAS 112 -42 -5)(Younger Labs, 1972). These substances are C10 and C11, and exemplary of the category trend of C6 -C12 alcohols in which the LC50 is expected to be greater than the substantially saturated vapour concentration. The recorded concentration in the key study is reported to be 700mg/m3. The saturated vapour concentration calculated using the ideal gas equation on the basis of the physicochemical properties of undecan-1 -ol implies that the highest theoretically achievable vapour concentration for undecanol is less than the reported value of 700mg/m3. Therefore the recorded concentration in the key study represents the highest possible exposure concentration and can be considered for classification purposes.
The key study for acute dermal toxicity, similarly, represents the category trend and the LD50 of undecanol, linear and monobranched C6 -C12 alcohols is expected to be of low toxicity.
In some cases the CAS and chemical identity stated refer to SDA nomenclature for this substance. in REACH substance identification it is necessary to be more specific as to the chain lengths present. Full details may be found in the CSR
Justification for classification or non-classification
Based on the chosen key information, there is no requirement for classification or labelling of the MCS #10 alcohol (undecanol, linear and monobranched), in accordance with current EC regulation 1272/2008. Tests on similar substances included in this category are also supportive of these results; which do not warrant classification for any acute toxicity endpoint under DSD or GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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