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Diss Factsheets
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EC number: 286-304-6 | CAS number: 85204-10-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to international guideline(s), GLP-compliant, performed in recognized contract research organization, no restrictions, fully adequate for assessment.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Test temperature:
- 25 °C (column temperature)
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:
- Type: Merck-Hitachi LaChrom HPLC system
- Type, material and dimension of analytical column: LiChrospher 100 CN 250 × 4 mm, 5µm HPLC Column No.: 540779-1
- Detection system: UV set at 205 nm
MOBILE PHASES
- Type: Acetonitrile:water 6:4, isocratic
- Solutes for dissolving test and reference substances: stock solutions were prepared in acetonitrile and diluted with HPLC mobile phase, except sodium nitrate which was dissolved in HPLC mobile phase
DETERMINATION OF DEAD TIME
- Method: by inert substance which is not retained by the column: sodium nitrate (RT = 1.30 min)
REFERENCE SUBSTANCES
- Identity (known log Koc): acetanilide (1.25), methyl benzoate (1.80), triazophos (2.55), naphthalene (2.75), fenthion (3.31), α-endosulfan (4.09)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: about 0.46 µg
- Quantity of reference substances: approx. 0.2 µg except for triazophos (approx. 0.46 µg) and sodium nitrate (approx. 2 µg)
- Intervals of calibration: three series of the reference solutions and the test item solution were measured alternately, with two replicate injections
REPETITIONS
- Number of determinations: two
EVALUATION
- Determination of the log Koc value: A calibration plot of log k' versus log Koc was prepared for the reference standards. The calibration equation was determined by linear regression using the least squares method. The capacity factors k' were calculated from the dead time and retention times of the reference substances. The log k' data of the reference substances were plotted against their log Koc values. - Key result
- Type:
- log Koc
- Value:
- <= 2.5
- Temp.:
- 25 °C
- Details on results (HPLC method):
- Approximately 94% (by chromatographic area) of the components of the test material were found to have Log Koc values below 1.25 (mean retention time ≤ 2.43 min). The remaining 6% eluted as one peak with a Log Koc value of 2.5 (mean retention time 3.29 min).
- Retention times of reference substances used for calibration:
sodium nitrate: 1.30, acetanilide: 2.75, methyl benzoate: 3.05, triazophos: 3.42, naphthalene: 3.48, fenthion: 3.67, α-endosulfan: 4.00 minutes
- Details of fitted regression line: log k' = 0.093 log Koc – 0.047 (Rsq = 0.966) - Validity criteria fulfilled:
- not applicable
Reference
Description of key information
Log Koc at 25 °C: ≤ 2.5 (HPLC method; OECD 121, EU C.19)
Key value for chemical safety assessment
Additional information
Approximately 94% of the components of the test material (by chromatographic area) were found to have Log Koc values of lower than 1.25. The remaining 6% eluted as one peak with a Log Koc value of 2.5.
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