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Diss Factsheets
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EC number: 278-758-9 | CAS number: 77745-66-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There were no signs of acute toxicity via the oral, dermal or inhalation routes.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 12 600 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
There are no indications of acute toxicity via the oral route for TiTDP (Lowe 2014). In addition, there was no acute toxicity via the oral, dermal or inhalation routes for close analogue - triisodecyl phosphite (TDP).
Use of TDP dermal acute toxicity data as read-across to TiTDP appears appropriate based on the similar acute toxicity of these alkyl phosphites. From the enhanced read-across justification (Section 13), it is also noted that the corresponding alkyl alcohols (hydrolysis products) for these phosphites also have low dermal toxicity.
Given the extremely low vapour pressure of TiTDP, it is not feasible to test via the inhalation route. Read-across data from TDP for the acute inhalation endpoint has been used in the CSR, though inhalation is not considered to be a major exposure pathway.
Justification for selection of acute toxicity – oral endpoint
No acute oral effects observed at the limit dose.
Justification for selection of acute toxicity – inhalation endpoint
No effects observed in an acute aerosol inhalation toxicty study done on close analog, triisodecyl phosphite. Substance is not volatile and inhalation exposure is not expected to occur so a waiver has been submitted for this endpoint.
Justification for selection of acute toxicity – dermal endpoint
No effects observed in an acute dermal toxicity study done on close analog, triisodecyl phosphite. Substance is classified as a skin sensitiser so exposure to skin is already being controlled. A waiver has been submitted for this endpoint.
Justification for classification or non-classification
The following information is taken into account for any hazard / risk assessment:
There were no signs of acute toxicity via the oral and read-across data from TDP suggests no acute toxicity via the dermal or inhalation routes.
The results justify non classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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