4-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]-N-(3-ethoxypropyl)benzenesulphonamide

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1993

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

no

Principles of method if other than guideline:

As per the guideline

GLP compliance:

no

Specific details on test material used for the study:

FAT 40444/A

Analytical monitoring:

not specified

Details on sampling:

None

Vehicle:

yes

Details on test solutions:

Water

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Details on test organisms:

No. of fish in each group: 7

Test type:

not specified

Water media type:

freshwater

Total exposure duration:

96 h

Test temperature:

ca. 23 °C

pH:

8.4 - 8.5

Dissolved oxygen:

89 - 97 %

Nominal and measured concentrations:

30, 100 and 300 mg/L

Reference substance (positive control):

no

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 300 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Details on results:

No mortality was observed at concentrations of 30 and 300 mg/L, however, 1 out of 7 fish died when exposed at 100 mg/L concentration.

Sublethal observations / clinical signs:

LC₁₀₀ >300 mg/L

Validity criteria fulfilled:

not specified

Conclusions:

96-h LC50 to fish was determined to be >300 mg/L.

Executive summary:

The acute toxicity of FAT 40444/A to fish was evaluated in a study conducted according to a methodology equivalent to OECD Guideline 203. Three groups, each containing 7 fish, were exposed to nominal test substance concentrations of 30, 100 and 300 mg/L for 96 h. No mortality was observed at concentrations of 30 and 300 mg/L, however, 1 out of 7 fish died when exposed at 100 mg/L concentration. Hence, the LC₅₀ was determined to be >300 mg/L.

Description of key information

The acute toxicity of FAT 40444/A to fish was evaluated in a study conducted according to a methodology equivalent to OECD Guideline 203. Three groups, each containing 7 fish, were exposed to nominal test substance concentrations of 30, 100 and 300 mg/L for 96 h. No mortality was observed at concentrations of 30 and 300 mg/L, however 1 out of 7 fish died when exposed at 100 mg/L concentration. Hence, the LC₅₀was determined to be >300 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

300 mg/L