4-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]-N-(3-ethoxypropyl)benzenesulphonamide

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2 November/2015 - 6 November 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

As per the guideline

GLP compliance:

no

Type of method:

flask method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Test material identified as: FAT 40444/B TE
- Source and lot No.of test material: PCR92X140707

OTHER SPECIFICS:
- Appearance: Red powder

Key result

Water solubility:

8.1 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

Remarks on result:

other: pH was not specified

Details on results:

Individual Results:
Preliminary Visual Estimation of the Water Solubility:
The preliminary visual experiments showed that the water solubility of the test item is < 0.01 g/L.

Flask-Method:
Average of 3 experiments: 0.0081 g/L

Solubility of the test item –experiments A to D

Experiment	A	B	C	D (blank)
Amount of test item (mg)	1000	1000	1000	-
Stirring time at 30 °C (h)	24	48	72	72
Measured concentration (mg/l)	0.0080	0.0100	0.0062	-
Dilution	-	-	-	-
n-Octanol solubility (g/l)	0.0080	0.0100	0.0062	-

 

Average experiments A to C: 0.0081 g/l

Conclusions:

The water solubility of FAT 40444/B at a temperature of 20 °C was determined to be 8.1 mg/L.

Executive summary:

The water solubility of FAT 40444/B was evaluated in a study conducted according to OECD 105 Guideline and EU Method A.6. Flask method was used for this purpose. The concentration of the test substance was determined by VIS-spectroscopy (509 nm).

The preliminary visual experiments showed that the water solubility of the test item is < 0.01 g/l. So, based on the findings of the study, the water solubility (without correction for the purity) of the test substance at a temperature of 20 °C was determined to be 8.1 mg/L.

Description of key information

The water solubility of FAT 40444/B was evaluated in a study conducted according to OECD 105 Guideline and EU Method A.6. Flask method was used for this purpose. The concentration of the test substance was determined by VIS-spectroscopy (509 nm). The preliminary visual experiments showed that the water solubility of the test item is < 0.01 g/l. So, based on the findings of the study, the water solubility (without correction for the purity) of the test substance at a temperature of 20 °C was determined to be 8.1 mg/L.

Key value for chemical safety assessment

Water solubility:

8.1 mg/L

at the temperature of:

20 °C