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EC number: 404-370-8 | CAS number: 126990-35-0 DCPMS; DYNASYLAN 9415; EURENOR 5023; SAN-30; WACKER SILAN CP2-DIMETHOXY; Z-6228
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06.11.1992 to 11.06.1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Only one dose tested
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dicyclopentyldimethoxysilane
- EC Number:
- 404-370-8
- EC Name:
- Dicyclopentyldimethoxysilane
- Cas Number:
- 126990-35-0
- Molecular formula:
- C12H24O2Si
- IUPAC Name:
- dicyclopentyldimethoxysilane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 155-195 g
- Fasting period before study: No
- Housing: Stainless steel cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Seven days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22± 2
- Humidity (%): 50± 20
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 19.11.1992 To: 07.12.1992
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus and chamber volume: 450 litre stainless steel and glass exposure chambers.
- Method of holding animals in test chamber: None
- Source and rate of air: Ambient filtered with hepa and charcoal filters. 12-15 air changes per hour.
- Treatment of exhaust air: No data
- Temperature, humidity, pressure in air chamber: Recorded every five minutes during the exposure period.
TEST ATMOSPHERE
- Brief description of analytical method used: Chamber concentrations were measured at least once per hour by a Varian 3400 Gas Chromatography.
- Samples taken from breathing zone: No data - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal: 33 ppm
Actual: 22 ppm
The saturated vapour concentration is approximately 52 ppm. The target exposure concentration of 30 ppm appears to have been unattainable under the conditions of this study as evidenced by the test substance deposition within the vapour generating and the gas chromatography sampling system. - No. of animals per sex per dose:
- Five
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed daily during the post-exposure period for clinical signs, mortality, general appearance and any evidence of respiratory, dermal, behavioural, nasal or ocular changes. Animals were weighed on days 1, 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: Gross pathological examination was conducted on all animals. The kidneys were examined microscopically. - Statistics:
- Statistical analyses were conducted on body weights. Data were analysed by a two-sided Welch Trend Test. All tests were conducted at the P≤ 0.05 level of significance.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 22 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No deaths.
- Mortality:
- No animals died.
- Clinical signs:
- other: None
- Body weight:
- No effects on body weights.
- Gross pathology:
- Pale kidneys were observed in 9/10 animals.
- Other findings:
- Histopathological examination of pale kidneys did not reveal any correlative microscopic lesions.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- In an acute inhalation study conducted using a protocol similar to OECD Test Guideline 403 and in compliance with GLP, the LD50 for dicyclopentyl(dimethoxy)silane was greater than 22 ppm, as no deaths occurred following a 4-hour exposure to this concentration. This concentration appeared to be the highest attainable under the conditions of this study.
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