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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 007
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Slag, pig iron ladle refining, non-granulated, water-cooled
- Molecular formula:
- not applicable because slags are UVCB
- IUPAC Name:
- Slag, pig iron ladle refining, non-granulated, water-cooled
- Details on test material:
- In order to substantiate this evaluation, the Tecarn-Tecnologia Ambiental Ltda accredited before the Ministry of Agriculture and is holder of bio-safety certificates.
SMS samples were collected in CST´s processing plants. The crushed stone is from Brasitalia quarry, located in the municipality of Serra, Brasilia. Crushed stone samples were collected and prepared by the company Kaerne Engenharia Ltda. In compliance with the method defined in NBR 10.007.2007.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Duration of exposure:
- 24 h, consecutive observation period 14 d
- Doses:
- their skin treated with the maximum dosage recommended for each product (4000 mg/kg)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- The animals were individually observed with special attention during the first 24 h after the administration of the test substance and for a period of 14 d when they were observed 7 d a week if evident signs were found, or 5 d a week when toxicity signs were not evident. The symptoms to be observed were alterations in the skin, fur, eyes and mucous membranes, dyspnoea, behaviour alterations, tremors, convulsions, salivation, diarrhea, lethargy, sleepiness, coma and death. In the case of mortality, the records include the approximate time of death.
Results and discussion
- Preliminary study:
- As it was known that there is no evidence of dermal toxicity, main test was made with maximum possible concentration of slags and crushed natural stone
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality reported
- Clinical signs:
- other: no clinical signs reported
- Gross pathology:
- no data
- Other findings:
- The monitoring of the animals included observation for alternations in the skin, fur, eyes and mucous membranes dyspnoea, behaviour alternations, tremors, convulsions, salivation, diarrhoea, lethargy, sleepiness, coma, and death. In case of death, the time of death would have been reported.
Any other information on results incl. tables
SMS LD50 > 4000 mg/kg
Crushed stone: LD50 > 4000 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- SMS: rats OECD 402: LD50 > 4000 mg/kg
Crushed natural stone: rats OECD 402: LD50 > 4000 mg/kg - Executive summary:
To test the dermal toxicity of slags, steelmaking (SMS), and crushed stone from a quarry in the vicinity of Serra, Brasilia, tests were performed following OECD guideline 402 in Wistar rats. Fine-ground SMS and crushed stone were dosed, in their original form, at 4 g/kg bw (body weight) under semi-occlusive dressing for 24 h. After dosing, the patches were removed and the animals were observed for a post exposure period of 14 days. The LD50 was > 4000 mg/kg bw for each test material.
Slags, steelmaking (SMS), and natural stone from a quarry in Serra, Brasilia, are not toxic via the dermal route, and do not need to be classified as dermal toxicants. No signal word and no hazard statement is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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