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EC number: 700-801-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan-Jun 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: the study was performed according to OECD guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Bottom product of propylene oxide and styrene production
- IUPAC Name:
- Bottom product of propylene oxide and styrene production
- Details on test material:
- - Name of test material (as cited in study report): KORE grade V
- Substance type: UVCB
- Physical state: Brown viscous liquid
- Stability under test conditions: months
- Storage condition of test material: room temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 1, 2, 4 8, 10 mg/L
- Sampling method: Specimens were collected from freshly prepared test solutions and those incubated for 48h of incubation.
- Sample storage conditions before analysis: The supporting analyse was performed on the same day of collection of the specimens.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test item was tested for toxicity towards daphnia as aqueous extracts (“WAF”) from up to 1000 mg test item/L (final concentration). For this purpose, different amounts of the test item were dispersed in dilution water. The elution of the water soluble part (WAF) of the test item took place on a shaking machine at 130 rpm speed over 24 h at room temperature, respectively. During that time an equilibration between the test item and the water was considered to be achieved. Thereafter, the suspensions were filtered through glass fibre filters in order to eliminate non-dissolved parts of the test item. The eluates were used for the test without further dilution steps.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: Daphnia magna STRAUS (clone 5)
- Source: of a laboratory breed (derived from Dr. M. Bergtold, BASF, D-67117 Limburgerhof; the strain originally derived from the Institut National de Recherche Chimique Appliquee, France in 1978 and cultivated since then at BASF using medium M4 acc. Elendt) was used for the test.
- Age at study initiation: not older than 24h
- Method of breeding: the cultivation of the daphnias is performed in a way that the animals are transferred in new test medium (see below) at an interval of 1 to 3 days followed by feeding with Desmodesmus subspicatus- and/or Chlorella-cells.
- Feeding during test: during the test the daphnia were not fed
ACCLIMATION: data not available
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- data not available
- Test temperature:
- between 20.8°C and 21.4°C
- pH:
- between 8.16 and 8.71
- Dissolved oxygen:
- control: 8.7 mg O2/L at T0 and 8.2 mg O2/L at T48
10 mg/L: 6.2 mg O2/L at T0 and 6.1 mg O2/L at T48 - Salinity:
- not applicable (freshwater)
- Nominal and measured concentrations:
- nominal concentration: 0, 1 .0, 2.0, 4.0, 8.0 and 10.0 mg/L
Mean measured concentration:SEE CHAPTER 10.2 OF THE REPORT - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL carboys made of glass
- Type (delete if not applicable): data not available
- Aeration: data not available
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: data not available
TEST MEDIUM / WATER PARAMETERS: test medium according Elendt M4 according to the guideline (prepared in ultra pure water)
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16h of light and 8h of darkness
- Light intensity: data not available
EFFECT PARAMETERS MEASURED: after 24h and 48h the number of immobilised daphnia at each concentration of the test item is recorded
TEST CONCENTRATIONS
- Spacing factor for test concentrations: =< 2
- Range finding study
- Test concentrations: 0, 1, 10, 100 and 1000 mg/L - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.61 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 2.13 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EL10
- Effect conc.:
- 1.81 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EL10
- Effect conc.:
- 0.62 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EL50
- Effect conc.:
- 2.1 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 0.92 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- In order to verify the sensitivity of the test system towards toxic items the effect of potassium dichromate towards different animals of this breed was tested prior to beginning of the test. The value of the EC50 (24h) in this period of time was 1.26 mg/L potassium dichromate. This value is in accordance with the recommendations given in OECD Guideline 202 (Daphnia sp., Acute Immobilisation Test).
- Reported statistics and error estimates:
- not applicable
Any other information on results incl. tables
Main Test
Loading of the testitem(mg/L) (Eluates/“WAF“) |
Ratio immobilised Daphnia [%] |
pH-Value
|
O2-Content [mg O2/L] |
Temperature [°C] |
|||||
24h |
48h |
t0 |
48h |
t0 |
48h |
t0 |
48h |
||
Control (0) |
0 [0/20]1) |
0 [0/20]1) |
8.71 |
8.44 |
8.7 |
8.2 |
20.9 |
21.1 |
|
1.0 |
|
0 [0/20]1) |
10 [2/20]1) |
8.39 |
8.30 |
6.4 |
7.5 |
20.2 |
20.8 |
2.0 |
|
0 [0/20]1) |
70 [14/20]1) |
8.24 |
8.16 |
6.3 |
7.3 |
20.4 |
21.0 |
4.0 |
|
55 [11/20]1) |
100 [20/20]1) |
8.21 |
8.24 |
6.4 |
6.6 |
20.3 |
21.4 |
8.0 |
|
100 [20/20]1) |
100 [20/20]1) |
8,32 |
8.22 |
6.3 |
6.4 |
20.3 |
21.1 |
10.0 |
|
100 [20/20]1) |
100 [20/20]1) |
8.39 |
8.23 |
6.2 |
6.1 |
20.4 |
21.1 |
1)Numbers in brackets give the absolute numbers of immobilised animals at each concentration.
Effective Concentrations (Loadings) on Basis of the Nominal Concentrations:
t24h |
t48h |
|
NOEC |
2.00 mg/L |
1.00 mg/L |
LOEC |
4.00 mg/L |
2.00 mg/L |
EL10 |
3.30 mg/L |
1.02 mg/L |
EL20 |
3.50 mg/L |
1.19 mg/L |
EL50 |
3.93 mg/L |
1.62 mg/L |
Effective Concentrations (Loadings) on Basis of the Measured Concentrations:
t24h |
t48h |
|
NOEC |
1.10 mg/L |
0.61 mg/L |
LOEC |
2.13 mg/L |
1.10 mg/L |
EL10 |
1.81 mg/L |
0.62 mg/L |
EL20 |
1.90 mg/L |
0.71 mg/L |
EL50 |
2.10 mg/L |
0.92 mg/L |
Results of the Analytical Part
Nominal Concentration [mg/L] |
mg/L TOC |
mg/L TOC |
% of t0 |
Mean Concentration TOC [mg/L] |
Calculated mean*)Concentration [mg/L] |
0 |
0 |
0 |
- |
0 |
0 |
1 |
0.39 |
0.65 |
166.3 |
0.50 |
0.61 |
2 |
0.72 |
1.14 |
158.5 |
0.90 |
1.10 |
4 |
1.69 |
1.83 |
108.1 |
1.76 |
2.13 |
8 |
3.53 |
3.08 |
87.3 |
3.29 |
3.99 |
10 |
4.30 |
4.40 |
102.3 |
4.35 |
5.27 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- In the control without any test item no dead animals were observed. In the test solutions the oxygen concen¬tration did not drop below a value of 60% of the saturation value (ca. 5 mg O2/L).
- Conclusions:
- EL50 (48h) 0.92 mg/L
NOEC (48h) 0.61 mg/L
LOEC (48h) 1.10 mg/L - Executive summary:
„KORE grade V“was tested for acute toxicity towards daphnia according to OECD-Test Guideline 202 (version dated 13-Apr-2004). In order to investigate the influence of the test item towards the daphnias, the swimming behaviour of the animals was recorded. Under the conditions used for the test, immobilisation of the daphnias was observed at concentrations representing the water soluble part (hereafter abbreviated “WAF”, water accommodated fraction) of the test item at concentrations up to 1000 mg/L. As a conclusion of the analytical part of this study, recoveries of the concentrations determined after 48h were at ≥ 80% of those determined at time t0, but furthermore,the measured concentrations of the treatments deviated more than 20 % from the nominal values. Based on this, the reported effect concentrations refer to mean measured concentrations (geometric mean) of the measured concentrations.The following EL-values (effective loading rate) were determined acordingly:
t24h
t48h
NOEC
1.10 mg/L
0.61 mg/L
LOEC
2.13 mg/L
1.10 mg/L
EL10
1.81 mg/L
0.62 mg/L
EL20
1.90 mg/L
0.71 mg/L
EL50
2.10 mg/L
0.92 mg/L
The test is considered valid as all conditions for validity were met.
· In the control without any test item no dead animals were observed.
· In the test solutions the oxygen concentration did not drop below a value of 60% of the saturation value (»5 mg O2/L).
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