Registration Dossier
Registration Dossier
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EC number: 241-475-6 | CAS number: 17462-58-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key value for chemical safety assessment
Additional information
Parent compound: no data. With the analogous compound isopropyl chloroformate, the key study comes from a respiration inhibition test performed similar to OECD TG 209 (BASF AG, 1983). It was conducted as a limit test with two control batches and one test batch. No inhibitory effects on activated sludge respiration were observed. The EC0 was 2527 mg/L. The study is regarded to also cover possible effects from the hydrolysis products isopropanol and HCl.
Hydrolysis product sec-butanol: Pseudomonas putida test 16 -h EC0 = ca. 500 mg/L (OECD, 2002)
Species | Results | Remarks | Reference |
Activated sludge | EC0 (30 min) = 2527 mg/L (nominal); respiration inhibition test (similar to OECD TG 209) | Analogous compound isopropyl chloroformate; reliability: 2, key study | BASF, 1983 |
Pseudomonas putida | EC0 (16 h) = ca. 500 mg/L (nominal); total biomass | Hydrolysis product sec-butanol; reliability: 2; key study | OECD, 2002 |
Chilomonas paramecium | EC0 (48 h) = ca. 745 mg/L (nominal); total biomass | Hydrolysis product sec-butanol; reliability: 2 | OECD, 2002 |
Entosiphon sulcatum | EC0 (72 h) = ca. 1282 mg/L (nominal); total biomass | Hydrolysis product sec-butanol; reliability: 2 | OECD, 2002 |
Uronema parduzci | EC0 (20 h) = ca. 1416 mg/L (nominal); total biomass | Hydrolysis product sec-butanol; reliability: 2 | OECD, 2002 |
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