Registration Dossier
Registration Dossier
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EC number: 202-784-1 | CAS number: 99-75-2
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset Substance ID: 99-75-2
- Author:
- IUCLID
- Year:
- 2 000
- Bibliographic source:
- http://esis.jrc.ec.europa.eu/ with reference to Montefibre S.p.A
- Report date:
- 2000
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs. Methyl p-toluate
- Author:
- Opdyke DLJ
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, Vol. 17 Suppl. 183-184
- Report date:
- 1979
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Maximization test according to Kligman, 1966 and Kligman and Epstein, 1975
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl p-toluate
- EC Number:
- 202-784-1
- EC Name:
- Methyl p-toluate
- Cas Number:
- 99-75-2
- Molecular formula:
- C9H10O2
- IUPAC Name:
- methyl 4-methylbenzoate
- Test material form:
- not specified
- Details on test material:
- 8 % test substance in petrolatum
- Name of test material (as cited in study report): RIFM no.77-344
Constituent 1
Method
- Type of population:
- general
- Controls:
- no data
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- One subject out of 25 volunteers showed sensitisation. This person reacted to a total of three test items within this test.
Applicant's summary and conclusion
- Conclusions:
- One case of sensitisation was observed within this study on 25 volunteers. Due to the reaction to other test items by this individual, it may be especially sensitive.
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