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Diss Factsheets
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EC number: 213-497-6 | CAS number: 959-26-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- The basis for this read-across approach is that the target substance is expected to undergo transformation into terephthalic acid (CAS No. 100-21-0) and ethane-1,2-diol (CAS No. 107-21-1). The toxicity of the transformation products will accurately predict the toxicity of the bis(2-hydroxyethyl)terephthalate (CAS No. 959-26-2). Refer to the JUSTIFICATION FOR READ-ACROSS OF TOXICOLOGICAL INFORMATION in Section 13 of this dossier for further details.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Specific details on test material used for the study:
- Prediction based on the toxicity of the transformation products terephthalic acid (100-21-0) and ethylene glycol (107-21-1)
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2 131 mg/L
- Basis for effect:
- inhibition of total respiration
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 8.4 mmol/L
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 2 131 mg/L
- Basis for effect:
- inhibition of total respiration
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 8.4 mmol/L
- Basis for effect:
- inhibition of total respiration
- Details on results:
- The 16d EC50 for terephthalic acid following OECD TG 209 is reported as 1392.8 mg/L (16d EC50 = 8.4 mmol/L).
The 16h Pseudomonas putida TTC, which is comparable with EC5, for ethylene glycol is reported as > 10000 mg/L (16h TTC > 161.1 mmol/L)
Based on a conservative prediction, the 3h EC50 of BHET is predicted to be > 2131 mg/L (3h EC50 > 8.4 mmol/L) - Validity criteria fulfilled:
- not applicable
- Remarks:
- Prediction based on analogue approach
- Conclusions:
- Based on a conservative prediction, the 3h EC50 of BHET is predicted to be > 2131 mg/L.
- Executive summary:
No data was available regarding the ability of BHET to inhibit activated sludge respiration. A GLP-compliant OECD 209 study was conducted with terephthalic acid. The respiration rate of activated sludge was not inhibited at saturated concentrations during the range finding study. The reported 16d EC50 was 1 392.8 mg/L or 8.4 mmol/L. The activated sludge respiration inhibition of ethylene glycol was assessed according to DIN 38412-8 using Pseudomonas putida. The 16-hour toxic threshold concentration (TTC), comparable with an EC5, was reported to be greater than 10 000 mg/L or 161.1 mmol/L. The information on the source substances is for longer exposure times than the 3-hour exposure period required by OECD 209 and would be a conservative estimate of the 3-hour respiration inhibition concentration. Information on the source substances is considered to be directly applicable to an equivalent molar amount of the target substance; therefore, the conservative 3h EC50 of BHET was predicted to be greater than 8.4 mmol/L or greater than 2 131 mg/L.
Reference
Description of key information
Based on a conservative prediction, the 3h EC50 of BHET is predicted to be > 2131 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 2 131 mg/L
- EC10 or NOEC for microorganisms:
- 2 131 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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