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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No signs of irritating to the skin of rabbits was observed. And it also failed to reveal that test substance is irritating to the rabbit eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

A study (Research & Consulting Company AG, 1988) was conducted according to OECD guideline in order to evaluate the risk potential of Alkyl (C13-C15)–glycidyl ether to the eyes. 0.1 ml of the substance was placed in the conjunctiva sac of the left eye of each rabbit and the right eye served as control. The results showed that only slight erythema was observed in the three rabbits after 1 hour and no abnormalities were observed after 24 h, 48 h and 72 h. The results indicated that the substance was not irritating to the eyes of rabbits. 

In addition, 0.5 ml of the substance was applied to the intact skin of the shaved areas of each rabbit for 4 hours and the untreated skin areas of the rabbit serve as the control. The results showed that the substance caused slight erythema during the examination period (at 24, 48 and 72 hours after patch removal). However, the reversibility of this reaction was observed at day 7 after the substance treatment. In addition, the score for erythema and oedema formation did not meet the criteria of any category for skin corrosion/irritation under CLP.

Based on the study results, it is concluded that the substance was not irritating to the skin and the eyes of the rabbits.

Justification for classification or non-classification

Based on the results, it can be concluded that test substance is non-irritating to the skin and the eyes of rabbits. Thus, test substance cannot be classified under the CLP (Regulation EC No. 1272/2008).