Alcohols C13-15 (branched and linear, odd numbered), reaction product with 1-chloro-2,3-epoxypropane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Non-GLP study for Epoxide 8 which has different exposure route concern comparing with the target material. Exposure concentrations were not measured. Limited documentation. Thus the study is used for read-across to avoid duplicate tests.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Materials and methods

Principles of method if other than guideline:

The test material was sprayed undiluted for fifteen seconds into an inhalation chamber containing four rabbits and ten rats. The chamber was sealed and flushed with air under reduced pressure for one hour. This procedure was repeated three times daily for
two days for the test material.
Necropsies were performed on each group of animals the morning following the last treatment. Blood and tissues were taken for examination.

GLP compliance:

no

Test type:

fixed concentration procedure

Test material

Test material information

Constituent 1

Reference substance name:

Epoxide 8

IUPAC Name:

Epoxide 8

Details on test material:

No data

Test animals

Species:

rat

Strain:

CD-1

Details on test animals or test system and environmental conditions:

Ten (10) Charles River CD Rats and four (4) New Zealand Albino Rabbits.

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

The test material was sprayed undiluted for fifteen seconds into an inhalation chamber containing four rabbits and ten rats. The chamber was sealed and flushed with air under reduced pressure for one hour. This procedure was repeated three times daily for two days for the test material.

Analytical verification of test atmosphere concentrations:

no

No. of animals per sex per dose:

10 rats and 4 rabbits

Results and discussion

Effect levels

Remarks on result:

other: No changes were found which related to the test treatment

Mortality:

No deaths

Clinical signs:

other: No symptoms noted

Body weight:

Average body weights were normal

Gross pathology:

No lesions were noted grossly in either species exposed to Epoxide No.8.

Other findings:

Microscopic examination of tissues showed no unusual changes except myocarditis in all four rabbits. The myocarditis was considered unrelated to test treatment since the population of rabbits being used had a higher than normal incidence of myocarditis.
Average blood values and organ/body weight-ratios were normal.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Epoxide No. 8 does not pose any apparent inhalation problem since it has a low toxicity and vapour pressure.

Executive summary:

The test material was sprayed undiluted for fiftheen seconds into an inhalation chamber containing four rabbits and ten rats. The chamber was sealed and flushed with air under reduced pressure for one hour. This procedure was repeated three times daily for two days for the test. material. Necropsies were performed on each group of animals the morning following the last treatment. Blood and tissues were taken for examination.

No lesions were noted grossly in either species exposed to Epoxide No.8. Microscopic examination of tissues showed no unusual changes except myocarditis in all four rabbits. The myocarditis was considered unrelated to test treatment since the population of rabbits being used had a higher than normal incidence of myocarditis. Average blood values and organ/body weight-ratios were normal.

Epoxide No. 8 does not pose any apparent inhalation problem since it has a low toxicity and vapour pressure.