Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-244-6 | CAS number: 3040-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The substance is readily biodegradable, but failing the 10-day window.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
- Type of water:
- freshwater
Additional information
Assessment:
The biodegradability of 2-piperidinoethanol was assessed in a GLP study according to OECD Guideline 301B. The degradation of the test item was determined to be 102±12% CO2/ThCO2 (mean±SD) after an exposure period of 28 days (BASF, 2019, Rep. No.: 22G0154/18G381). The degree of biodegradation at the end of the ten-day window was approx. 52% CO2/ThCO2 (mean value). Hence, the required pass level for ready biodegradability in accordance to the OECD Guideline 301B (at least 60% of the theoretical CO2 production must be attained within 10 days of the degradation exceeding 10% within the 28-day period of the test) was not accomplished. Therefore, 2-Piperidinoethanol fails the OECD criteria for ready biodegradability in this carbon dioxide evolution test according to OECD 301B. This result was selected as key result.
Additionally in a batch test according to OECD 302B, 2-piperidinoethanol was easily eliminated from water (BASF, 1985, Report No. 1251) after 18 days (100% DOC removal). However, a lag phase of approx. 10 days and the sigmoidal shape of the elimination curve are evidences for the inherent biodegradability of the test substance. This result was selected as supporting study.
The ready biodegradability was also assessed using the BOD 28 days MITI (OECD 301C) model (v11.16) of CATALOGIC v5.14.1.5 (BASF, 2021). The degradability was 78% (O2 consumption). The test substance was found to be readily biodegradable in water according to the BIOWIN v4.10 model of EPI Suite v4.11 (BASF SE, 2018). The substance was within the applicability domain of both models. These results were selected as supporting studies.
In conclusion, the substance is assessed to be readily biodegradable but failing the 10-day window (according to OECD criteria).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.