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Diss Factsheets
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EC number: 445-090-6 | CAS number: 5614-37-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 March 2003 - 07 April 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in compliance with EC and OECD test guidelines, and in compliance with GLP, so the study is considered reliable without restriction.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Analytical purity: 99.9%
- Lot/batch No.: 020618 - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: Immediately after spiking of buffer solution (t=0), 2.4 hours, and 5 days.
- Sampling method: Liquid-liquid extraction using dichloromethane
- Sampling methods for the volatile compounds, if any: N/A - samples were transferred to glass vials to give a minimum of headspace. - Buffers:
- pH 4 buffer
0.1M potassium dihydrogen citrate solution was adjusted to pH 4.0 with 1M sodium hydroxide, with the temperature of the buffer solution at 50°C ± 0.5°C.
pH 7 buffer
0.1M potassium dihydrogen orthophosphate solution was adjusted to pH 7.0 with 1M sodium hydroxide, with the temperature of the buffer solution at 50°C ± 0.5°C.
pH 9 buffer
0.1M solution of potassium chloride and boric acid was adjusted to pH 9.0 with 1M sodium hydroxide, with the temperature ofthe buffer solution at 50°C ± 0.5°C. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50
- Duration:
- 5
- pH:
- 7
- Temp.:
- 50
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50
- Number of replicates:
- Performed in duplicate for each pH
- Positive controls:
- no
- Negative controls:
- yes
- Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Conclusions:
- The results indicate that at 25°C, NZE will possess a half-life time of greater than 1 year at pH 4, pH 7 and pH 9.
Reference
Under the test conditions, NZE did not undergo hydrolysis giving final recoveries of 107.9% at pH 4, 107.5% at pH 7 and 104.5% at pH 9 after 5 days at 50°C.
According to the test method it can be estimated that:
10% hydrolysis occurring in 5 days at 50°C is equivalent to a half-life time of 1 year at 25°C.
50% hydrolysis occurring in 2.4 hours at 50°C is equivalent to a half-life time of 1 day at 25°C.
Applying these criteria to the results obtained for NZE, the half-life at 25°C can be estimated as being greater than 1 year at pH4, pH7 and pH9.
Description of key information
Half-life greater than 1 year at 25°C at pH4, pH7, and pH9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
A determination of the abiotic degradation (hydrolysis) potential of the substance was conducted (Huntingdon Life Sciences, 2003). The study was performed according to OECD method 111 and EC test guideline C7, and was conducted in compliance with GLP.
After a period of 5 days at 50°C, the substance did not undergo hydrolysis at pH4, pH7, or pH9.
The results indicate that at 25°C, the substance will have a half-life of greater than 1 year at pH4, pH7, and pH9.
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