Registration Dossier
Registration Dossier
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EC number: 239-481-9 | CAS number: 15467-06-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: cf justification
- Principles of method if other than guideline:
- Évaluer le potentiel d'irritation oculaire de l'adipate de diéthylhexyle
- GLP compliance:
- not specified
Test material
- Reference substance name:
- butyl (9Z,12R)-12-(acetyloxy)octadec-9-enoate
- Cas Number:
- 140-04-5
- Molecular formula:
- C24H44O4
- IUPAC Name:
- butyl (9Z,12R)-12-(acetyloxy)octadec-9-enoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Bis(2-ethylhexyl) adipate
- Molecular formula : C22H42O4
- Molecular weight : 370.57 g/mol
- Smiles notation : C([C@@H](CCCC)CC)OC(CCCCC(OC[C@@H](CCCC)CC)=O)=O
- InChl : 1S/C22H42O4/c1-5-9-13-19(7-3)17-25-21(23)15-11-12-16-22(24)26-18-20(8-4)14-10-6-2/h19-20H,5-18H2,1-4H3
- Substance type: Organic
- Physical state: Liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albinos
- Details on test animals or tissues and environmental conditions:
- non spécifié
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- non spécifié
- Observation period (in vivo):
- non spécifié
- Duration of post- treatment incubation (in vitro):
- non spécifié
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- non spécifié
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: non spécifié
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- L'adipate de diéthylhexyle non dilué n'irritait pas les yeux du lapin.
Any other information on results incl. tables
aucun
Applicant's summary and conclusion
- Interpretation of results:
- other: non irritant
- Conclusions:
- L'adipate de diéthylhexyle non dilué n'irritait pas les yeux du lapin.
- Executive summary:
Une étude d'irritation des yeux a été menée pour évaluer le potentiel d'irritation oculaire de l'adipate de diéthylhexyle chez les lapins.
0,1 ml d'adipate de diéthylhexyle non dilué a été instillé dans les yeux de 6 lapins albinos, les yeux sont restés non lavés et les effets ont été observés (durée non précisée).
L'adipate de diéthylhexyle non dilué n'irritait pas les yeux du lapin.
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