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EC number: 301-037-8 | CAS number: 93980-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study period: 15 - 17 Nov 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L, sampled at test start end end of exposure period.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test sample (0.100 g) and dilution water (1000 mL) were mixed to produce the nominal concentration of 100 mg/L, and they were stirred with a magnetic stirrer for 48 hours at about 20°C to prepare the test solution.
The test solution in the exposure level was white suspended at the start of exposure. At the end of exposure, the test solution in the exposure level was slightly white suspended and precipitation and insoluble matter were observed. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Source: The University of Sheffield, UK
- Age of parental stock (mean and range, SD): 14 d
- Feeding during test: no
ACCLIMATION
- Acclimation period: 14 d
- Acclimation conditions (same as test or not): same
- Type and amount of food: Chlorella vulgaris of 0.1- 0.2 mgC (Organic carbon content)/day per Daphnia once a day.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 32 mg/L
- Test temperature:
- 19.9 - 20.1 °C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 8.8 - 9.0 mg/L
- Nominal and measured concentrations:
- Nominal test substance concentration: 100 mg/L
Measured test substance concentration: < LOD of 0.521 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beaker (100 mL)
- Type (delete if not applicable): covered with transparent plastic lid
- Fill volume: 100 mL
- Aeration: no aeration
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated Tap water
- Total organic carbon: < 0.5 mg/L
- Conductivity: 13 mS/m
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16:8 h day-night regime
EFFECT PARAMETERS MEASURED (with observation intervals if applicable)
- Mobility after 24 and 48 h
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: none observed
- Mortality of control: none
Since the concentration of the test item in the test solution during exposure was less than the determination limit value ( <0.536 mg/L), neither dissolution concentration nor the stability in the exposure period was clear. However, no effects on test organisms were observed, indicating that the test item exert no acute effect on test organisms at around the solubility in dilution water. - Results with reference substance (positive control):
- Latest test date: 18 - 20 October 2017
48-hour EC50: 0.12 mg/L (mean± 2 S.D.: 0.10-0.35 mg/L,n= 102) - Validity criteria fulfilled:
- yes
- Remarks:
- For further details please refer to “Any other information on results incl. tables”.
Reference
Table 1: Survival of D. magna.
Nominal concentration [mg/L] | Test Vessel | Number of immobilised daphnids/Total daphnids after 48 h |
Immobility [%] |
Control | A | 0/5 | 0 |
B | 0/5 | ||
C | 0/5 | ||
D | 0/5 | ||
100 | A | 0/5 | 0 |
B | 0/5 | ||
C | 0/5 | ||
D | 0/5 |
Table 2: Validity criteria for OECD 202.
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
In the control, including the control containing the solubilising agent, not more than 10% of the daphnids should have been immobilized. |
0% immobilised |
yes |
The dissolved oxygen concentration at the end of the test should be ≥ 3 mg/L in control and test vessels. |
8.8 - 9.0 mg/L |
yes |
Description of key information
EC50 (48 h) >100 mg/L (nominal)
Key value for chemical safety assessment
Additional information
The acute toxicity of the test substance to aquatic invertebrates was tested in a study following OECD guideline 202 (GLP). Daphnia magna were exposed to a nominal test substance concentration of 100 mg/L in a static limit test. The nominal concentration was analytically verified by HPLC. The test substance concentration was below the determination limit of the method of 0.521 mg/L reflecting the very low water solubility of the substance of 0.525 mg/L at 20 °C, pH 5.9.
During the exposure period of 48 hours mortality or behavioural abnormalities were not observed. The reported EC50 (48 h) is >100 mg/L (nominal).
Based on the results acute toxic effects on aquatic invertebrates are not expected within the range of water solubility.
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