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EC number: 269-284-3 | CAS number: 68214-04-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 October 2007 to 28 November 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: test according to the guideline under GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0 and 667 mg/L
- Sampling method: sample from the freshly prepared test media and pooled sample at 48 hours at 0 and 667 mg/L (at 667 mg/L analysed in duplicate)
- Sample storage conditions before analysis: frozen at < -10°C - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION as such in reconstituted water
- Controls: reconstituted water - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Strauss
- Source: ECT Oekotoxikologie GmbH, Böttgerstr. 2 - 14, 65439 Flörsheim am Main, Germany.
- Age at study initiation: 6.25 to 15.25 hours
- Method of breeding: conditions similar to test conditions (fed Tetramin once weekly)
- Feeding during test: none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg/L as CaC03
- Test temperature:
- 19-20 °C
- pH:
- 7.6
- Dissolved oxygen:
- 8.2-8.7 mg/L (90-96% of saturation)
- Salinity:
- N/A
- Nominal and measured concentrations:
- nominal 0 and 677 mg/L
measured: at 0 and 48 hmeasured a.i.: 0 and 100 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beaker filled with 80 mL test medium
- Type: closed
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
In deionised water (conductivity < 5 uScm-l) analytical grade salts were added at the following nominal concentrations:
CaC12 X 2H20 2.0 mmol/L (= 294 mg/L)
MgS04 X 7H20 0.5 mmol/L (= 123 mg/L)
NaHC03 0.75 mmol/L (= 65 mg/L)
KC1 0.075 mmol/L (= 5.8 mg/L)
Water Hardness : 2.5 mmol/L (= 250 mg/L) as CaC03
Alkalinity : 0.8 mmol/L
Ratio of Ca : Mg = 4 : 1 (based on molarity)
Ratio of Na : K = 10 : 1 (based on molarity)
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod: 16 hours light
- Light intensity: 90-150 lux
EFFECT PARAMETERS MEASURED : immobility at 24 and 48 hours
TEST CONCENTRATIONS: 0 and 667 mg/L (based on non-GLP rang finding study) - Reference substance (positive control):
- yes
- Remarks:
- KOH tested twice yearly
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 667 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- measured concentration is 105% of nominal
mortality: 0% in controls , 35% at 667 mg/L - Results with reference substance (positive control):
- 48 h EC50 1.6 mg/L
- Reported statistics and error estimates:
- NA
- Validity criteria fulfilled:
- yes
- Remarks:
- mortality in controls < 10% and oxygen concentration > 3 mg/L
- Conclusions:
- The EC50 of the test material is > 667 mg/L
The EC50 of the substance is > 100 mg/L - Executive summary:
The substance (15% formulation) was tested in Daphnia magna (n=20, 4 replicates/concentration) according to OECD 202 in a static limit test. After 48 hours 35% immobility was seen at 667 mg/L (100 mg/L a.i.). The EC50 based on active ingredient is >100 mg/L.
Reference
Description of key information
The substance (15% formulation) was tested in Daphnia magna (n=20, 4 replicates/concentration) according to OECD 202 in a static limit test. After 48 hours 35% immobility was seen at 667 mg/L (100 mg/L a.i.). The EC50 based on active ingredient is >100 mg/L (IBACON 2007)
In a study performed according to OECD 202, daphnids were exposed to a formultion of the substance during 48 hours. Effects on mobility were found at 10 mg/L and above (based on test item). The EC50 is 10.4 mg/L (based on a.i.). The publication contains only limited information and it is not clear whether other components of the formulation may have influenced this result (Darsana 2015).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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