Registration Dossier
Registration Dossier
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EC number: 224-580-1 | CAS number: 4418-26-2
Endpoint summary
Administrative data
Description of key information
Additional information
The dataset for aquatic toxicity is not complete for the substance dehydroacetic acid, sodium salt(CAS 4418-26-2). Therefore, read-across to a structurally related substance was conducted in order to fulfil the standard information requirements in compliance with Annex XI, 1.5, of Regulation (EC) N° 1907/2006. Dehydroacetic acid (CAS 520-45-6) was selected as source substance and considered suitable for the assessment of the target substance Dehydroacetic acid sodium salt based on its chemical and structural similarity.
With this read-across approach, data is available for three trophic levels (fish, aquatic invertebrates and algae). For the short-term toxicity to aquatic invertebrates and microalgae, reliable guideline studies for the substance itself(CAS 4418-26-2)are available. These studies were performed according to internationally accepted guidelines and GLP.The available data suggests that aquatic freshwater microalgae are the most sensitive trophic level, for which a nominal ErC10 (72 h) value of 23.9 mg/L (11.3 – 31.5 mg/L, 95% confidence interval) and an ErC50 (72 h) value of 32.1 mg/L (14.3 – 69.9 mg/L, 95% confidence interval) was obtained.The short-term toxicity test to aquatic invertebrates resulted in an EC50 (48 h) of > 100 mg/L (nominal).
The toxicity control in the biodegradation test (301 F) indicates that the substance is not toxic to aquatic microorganisms and resulted in a NOEC (14 d) of 38 mg/L (nominal).
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