Registration Dossier
Registration Dossier
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EC number: 273-727-6 | CAS number: 69012-27-7 By-product of chromium refining containing oxides of aluminum, magnesium and silicon.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
No genotoxicity data of ferrochromium slag exists.
The amorphous glass phase of FeCr-slag consists of practically insoluble silicates, and therefore it is seen justified to use read-across to studies on synthetic amorphous silica, calcium silicate, sodium aluminium silicate, kaolin (an Al-silicate) and nonfibrous glass (containing Ca-, Al, Mg- and borosilicates).
. In vitro and in vitro tests non-fibrous silicates have not shown genotoxic activity.The dissolution of the metal cations (Al, Ca, Mg, Fe, Cr) and hexavalent chromium are very low, usually below their analytical detection limits. Based on their unsubstantial bioavailabilty any genotoxicity caused by these substances can be omitted. The metallic droplets are embedded in the glass phase, and if otherwise, they are covered by a inactive chromium(III) oxide layer. Chromium(III) compounds have not shown genotoxicity.
Several silicates (eg. Al-, Ca-, CaAl-, Mg-, NaAl-silicates) are allowed food additives and cosmetics ingredients.
Short description of key information:
No genotoxicity data of ferrochromium slag exists. The slag was assumed to have toxicological properties similar to those of practically insoluble silicates.
In vitro and in vitro tests of non-fibrous silicates have not shown genotoxic activity.
The metallic droplets are embedded in the glass phase, and if otherwise, they are covered by a inactive chromium(III) oxide layer. Chromium(III) compounds have not shown genotoxicity.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Ferrochromium slag is not classificable for genotoxicity.
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