Registration Dossier
Registration Dossier
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EC number: 694-898-7 | CAS number: 23121-00-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Jan - 11 Feb 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted in 1987
- Deviations:
- yes
- Remarks:
- No detailed documentation
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-(2-phenylpropan-2-yl)phenyl 4-oxo-3-(λ⁵-diazynylidene)-3,4-dihydronaphthalene-1-sulfonate
- Cas Number:
- 23121-00-8
- Molecular formula:
- C25H20N2O4S
- IUPAC Name:
- 4-(2-phenylpropan-2-yl)phenyl 4-oxo-3-(λ⁵-diazynylidene)-3,4-dihydronaphthalene-1-sulfonate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Hoe: WISKf (SPF71)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breeding (Hoechst Aktiengesellschaft Pharma Forschung Toxikologie, Germany)
- Females nulliparous and non-pregnant: not specified
- Weight at study initiation: 202 - 220 g (range)
- Fasting period before study: animals were fasted for 16 h prior to and 2 h after administration
- Housing: group caged in plastic cages, on softwood granulate
- Diet: ALTROMIN 1324 (Altromin GmbH, Lage/Lippe, Germany), ad libitum
- Water: tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 females
- Control animals:
- no
- Remarks:
- , not required
- Details on study design:
- - Duration of observation period following administration: 21 days
- Frequency of observations and weighing: the animals were observed for mortality and for clinical signs at unspecfied intervals during the observation period, the body weight was recorded weekly
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Two rats died between Day 12 and 13.
- Clinical signs:
- other: An unknown nnumber of rats showed crouching, piloerection, restlessness, high-stepping gait and sunken flanks. No clinical signs of toxicity were observed at 14 days after application.
- Gross pathology:
- No necropsy of the two deceased rats could be performed, because they were (partly) eaten by the surviving rats. No abnormal gross findings were identified in the surviving rats following sacrifice.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/ EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- CLP: not classified
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