Registration Dossier
Registration Dossier
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EC number: 225-403-0 | CAS number: 4826-71-5
Endpoint summary
Administrative data
Description of key information
The available data refer to the degradation products of calcium phosphorylcholine chloride (choline and inorganic phosphate):
Short-term toxicity to fish:
- Key study. Method according to OECD 203. GLP study. The 96h-LC50 of the substance choline chloride in Oryzias latipes was higher than 100 mg/L (nominal), based on mortality.
- Key study. Method according to OECD 203. GLP study. The 96h-LC50 of the substance calcium hydrogenorthophosphate in Oryzias latipes was above 100 mg/L (nominal) and the NOEC was 100 mg/L, both based on mortality.
Short-term toxicity to aquatic invertebrates:
- Key study. Method according to OECD 202. GLP study.The 48h-EC50 of choline chloride in Daphnia magna was determined to be 349 mg/L (nominal) and the 48h-NOEC was determined to be 180 mg/L (nominal), both based on mobility.
- Key study. Method according OECD to 202. GLP study.The 48h-EC50 of calcium hydrogenorthophosphate in Daphnia magna was higher than 100 mg/L (nominal) and 2.9 mg/L (measured), based on mobility.
Long-term toxicity to aquatic invertebrates
- Key study. OECD 211. GLP study.The 21 day-EC50 of choline chloride in Daphnia magna was 58.9 mg/L and the 21 day-NOEC was 30.2 mg/L.
Toxicity to aquatic algae and cyanobacteria
- Key study. OECD 201. GLP study.The 72h-EC50 (based on growth rate reduction) of choline chloride in Pseudokichneriella subcapitata was greater than 1000 mg/L and the 72h-NOEC was 1000 mg/L.
- Key study. OECD 201. GLP study.The 72h-EC50 of calcium hydrogenorthophosphate in Pseudokirchneriella subcapitata was found to be higher than 100 mg/L (nominal) and the NOEC was determined to be 100 mg/L, both based on growth rate.
Toxicity to microorganisms
- Key study. Method according OECD 301. The test item was not inhibitory to microorganisms (93.5% biodegradation in 14d) at a concentration of 100 mg/L. Therefore, the NOEC value for the test item in microorganisms is greater than 100 mg/L.
Based on this information, it can be concluded that the substance phosphoryl choline chloride has an 96h-LC50 in Oryzias latipes above 100 mg/L, a 48h-EC50 in Daphnia magna higher than 100 mg/L, a 72h-EC50 in Pseudokirchneriella subcapitata higher than 100 mg/L and a NOEC for microorganism toxicity of 100 mg/L.
Additional information
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