4-hydroxy-3-methoxycinnamic acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1957

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Qualifier:

no guideline followed

Principles of method if other than guideline:

All compounds were tested at an initial concentration of 5 ppm. Test were conducted for a 24-hour period at a water temperature of 55 deg. F.

GLP compliance:

no

Analytical monitoring:

no

Test organisms (species):

other: Oncorhynchus mykiss (previous name: Salmo gairdneri) and Lepomis macrochirus

Details on test organisms:

Test fishes were of fingerling size, 4 Inches or slightly less in length; every effort was made to keep size variation at a minimum.

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

24 h

pH:

7.5 to 8.2

Dissolved oxygen:

8.6 to 1.7 ppm

Nominal and measured concentrations:

one concentration tested = 5 mg/L (5 ppm)

Details on test conditions:

Water used in all tests was drawn from a supply pumped directly from Hammond Bay of Lake Huron.
Test fishes were obtained from the stocks of locel state and Federal fish haldleries and were held in large raceways. These specimens were maintained in the best p ssible physical condition until used in the laboratory.

Reference substance (positive control):

no

Key result

Duration:

24 h

Dose descriptor:

EC0

Effect conc.:

5 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Key result

Duration:

24 h

Dose descriptor:

NOEC

Effect conc.:

5 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

not applicable

Conclusions:

With the Ferulic acid no effet were recorded after 24 h of exposure on larvae of the Sea lamprey (Petromyzon marinus) or on rainbow trout or on bluegill sunfish.

Executive summary:

In this study, several compounds (more than 4000) were tested at an initial concentration of 5 mg/L. Test were conducted for a 24-hour period at a water temperature of 55 deg. F. Observations on the toxic effect of compounds were made on larvae of the sea lamprey (Petromyzon marinus) and also on rainbow trout and bluegill sunfish.

With the Ferulic acid no effect were recorded after 24 h of exposure on larvae of the Sea lamprey (Petromyzon marinus) or on rainbow trout or on bluegill sunfish.

.

Description of key information

Only one study was found for the fish.

This publication does not cover the essential principal of the OECD guideline test (i.e. only 24 hours exposure, test performed on larvae, concentration etc…) however as there is no other data found on the fish with the ferulic acid this study was used for this trophic level.

Nevertheless in this study, with the Ferulic acid at 5 mg/L no effect were recorded after 24 h of exposure on larvae of the Sea lamprey (Petromyzon marinus) or on rainbow trout or on bluegill sunfish.

 

As the only concentration tested was 5 mg/L, it cannot be used as key value for this trophic level.