Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 202-896-0 | CAS number: 100-86-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Screening of fragrance materials for allergenicity in the guinea pig I. Comparison four testing methods
- Author:
- G. KLECAK, H. GELEICK, and J. R. FREY
- Year:
- 1 975
- Bibliographic source:
- J. Soc. Cosmet. Chem.,28, 53-64 (February 1977)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- There are available GPMT , OET , DT and FCAT data and they are enough for hazard assessment for skin sensitization.
Test material
- Reference substance name:
- 2-methyl-1-phenylpropan-2-ol
- EC Number:
- 202-896-0
- EC Name:
- 2-methyl-1-phenylpropan-2-ol
- Cas Number:
- 100-86-7
- Molecular formula:
- C10H14O
- IUPAC Name:
- 2-methyl-1-phenylpropan-2-ol
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Himalayan
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Institute of Biomedical Research, Füllinsdorf, Switzerland
- Weight at study initiation: 400 to 500g
- Diet (e.g. ad libitum): pelleted feed supplemented with green vegetables, carrots and vitamin C
- Water (e.g. ad libitum): drinking water, ad libitum
Study design: in vivo (non-LLNA)
- Details on study design:
- On day 0 the animals were injected intradermally with 0.1 ml of a 5 percent solution of the compound tested, with 0.1 ml of a 5 percent emulsion of the same compound in Freund's complete adjuvant (FCA) and with 0.1 ml of FCA alone, each injection being given twice. In addition, 250 mg of the compound dissolved in petrolatum at a concentration of 25 percent, which always causes mild to moderate skin irritation under occlusionw, asa pplied on day 8 to a clipped skin area of the neck and was kept under occlusive bandage for 2 days (total dose 20 mg intradermally plus 250 mg epicutaneously). On day 21 an occlusive patch test with the compound at a subirritant concentrationin petrolatum was applied to the flank for 24 h. The reactions were read 24 and 48 h after removing the patch.
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Group:
- test chemical
- Remarks on result:
- no indication of skin sensitisation
- Group:
- negative control
- Remarks on result:
- not measured/tested
- Group:
- positive control
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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