Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-896-0 | CAS number: 100-86-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VIII
- Author:
- Carpenter, Weil and Smyth.
- Year:
- 1 974
- Bibliographic source:
- Toxicol Appl Pharmacol 28, 313-319.
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth Jr., Carpenter, Well, Pozzani and Striegel.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 23:2, 95-107
- Reference Type:
- publication
- Title:
- Chemical Burns of the Rabbit Cornea
- Author:
- Carpenter and Smyth
- Year:
- 1 946
- Bibliographic source:
- American Journal of Ophthalmology Vol. 29 (11), Pages 1363-1372
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The method is described in Smyth et al., 1962 and Carpenter and Smyth 1946. Eye irritation was evaluated using 5 albino rabbits per dose. The test material was applied to the centre of the cornea while the lids are retracted, and approximately 1 minute later, the lids are released. The eye was examined in strong diffuse daylight 18 - 24 hours later, stained with fluorescein, and the injury scored. No vehicle was used.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methyl-4-phenylbutan-2-ol
- EC Number:
- 203-074-4
- EC Name:
- 2-methyl-4-phenylbutan-2-ol
- Cas Number:
- 103-05-9
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2-Methyl-4-phenyl-2-butanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- Undiluted
- Duration of treatment / exposure:
- 18 - 24 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corneal necrosis
- Basis:
- mean
- Time point:
- other: Only 24hr timepoint
- Score:
- 8
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating
- Conclusions:
- Phenylethyl Alcohol is an irritant to rabbit eyes.
- Executive summary:
In an eye irritation study (Carpenter et al., 1974) Phenylethyl Alcohol (undiluted) was applied to the centre of the cornea of 5 albino rabbits. The eye was examined in strong diffuse daylight 18 - 24 hours later, stained with fluorescein, and the injury scored. No vehicle was used.
Eye injury was graded according to the following 10-point scale based upon the degree of corneal necrosis that resulted. The corneal injury in rabbits was indicated as 8 out of 10. Based on the results of this study, Phenylethyl Alcohol was considered to be an eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)