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EC number: 250-379-3 | CAS number: 30899-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The bioaccumulation potential of Lauric acid ester with hydroxypropanediyl diacetate (CAS 30899-62-8) is expected to be low based on all available data.
Key value for chemical safety assessment
Additional information
Experimental data investigating the bioaccumulation potential of Lauric acid ester with hydroxypropanediyl diacetate (CAS 30899-62-8) are not available. The substance has a log Pow of 5.27 - 10.18 indicating a potential to bioaccumulate in biota. However, the information gathered on environmental behaviour and metabolism in combination with the QSAR-estimated BCF values provide enough evidence (in accordance with REACh Regulation (EC) No. 1907/2006, Annex IX General rules for adaptation of the standard testing regime set out in Annexes VII to X, 1.2, to cover the data requirements of Regulation (EC) No. 1907/2006, Annex VII) to state that the substances is not likely to bioaccumulate.
Due to the low water solubility (<0.15 mg/L at 20 °C and pH=6.2 - 6.6) and high estimated adsorption potential (log Koc: 4.24 - 6.86 (MCI method); 3.71 - 6.43 (based on log Kow)) of the substance significant removal of the substance in conventional STPs can be expected. The Guidance on information requirements and chemical safety assessment, Chapter R.7b, states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms (ECHA, 2016). Therefore, after passing through conventional STPs, only low concentrations of these substances are likely to be (if at all) released into the environment.
If released to the water the substance will tend to bind to sediment and other particulate organic matter due to their hydrophobicity and relatively high adsorption potential. The actual dissolved fraction available to fish via water is assumed to be low (Mackay and Fraser, 2000). Thus, the most relevant exposure route for aquatic organisms such as fish will be via food ingestion or contact with suspended solids. If the substance is ingested by organisms a fast metabolisation is expected. After lipid content, the degree of biotransformation seems to be the most relevant factor regarding the bioaccumulation of organic chemicals in aquatic organisms (Katagi, 2010). Biotransformation consists in the conversion of a specific substance into another/other (metabolites) by means of enzyme-catalyzed processes (ed. van Leeuwen and Hermens, 1995). Carboxylesterases are a group of ubiquitous and low substrate specific enzymes, involved in the metabolism of ester compounds in both vertebrate and invertebrate species, including fish (Leinweber, 1987; Barron et al., 1999). Glycerides, especially triglycerides, are the predominant lipid class in the diet of both marine and freshwater fish. Once ingested, they will be enzymatically hydrolyzed into fatty acids and glycerol by a specific group of carboxylesterase (CaE) enzymes (lipases) as reported in different fish species (Tocher, 2003). Part of the free fatty acids will be re-esterified once more with glycerol and partial acyl glycerols to form triglycerides, that will be stored as long-term energy reserves. Glycerol is naturally present in animal and vegetable fats, rarely found in free state (mostly combined with fatty acids forming triglycerides) (ed. Knothe, van Gerpen and Krahl, 2005). If freely available in aquatic organisms, it will not bioaccumulate in view of its log Kow value of -1.76 (OECD SIDS, 2002). Especially in periods in which the energy demand is high (reproduction, migration, etc.), glycerides are mobilized from the storage sites as source of fatty acids. Fatty acid catabolism is the most important energy source in many species of fish, resulting in the release of acetyl CoA and NADH (through β-oxidation) and eventually, via the tricarboxylic cycle, the production of metabolic energy in the form of ATP. This fatty acid-catabolism pathway is the predominant source of energy related to growth, reproduction and development from egg to adult fish. A similar metabolic pathway is observed in mammals (see section 7.1.1 Basic toxicokinetics). Additional information on the bioaccumulation of Glycerides in fish species is available. Estimated bioconcentration (BCF) and bioaccumulation (BAF) values were calculated for the substance using the BCFBAF v3.01 program (Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10., US EPA), assuming biotransformation (Arnot-Gobas method). The estimated BCF and BAF values were 0.913 - 12.3/0.914 - 12.3 L/kg, respectively. These models have no universally accepted definition of model domain, but since one component is outside the Kow range of the training set (log Kow range of the training set: 0.31-8.70; log Kow of the substance: 23.72), the results should be taken with caution. However, the smaller component of the substance is within the applicability domain of the model and thus the result is fully reliable indicating a low potential for bioaccumulation.
Conclusion
The substance Lauric acid ester with hydroxypropanediyl diacetate (CAS 30899-62-8) is not expected to be bioaccumulative. The substance is expected to be extensively eliminated in conventional STPs and only low concentrations are expected to be released (if at all) to the environment. If the substance is taken up by fish species, extensive and fast biotransformation of the substance by carboxylesterases into fatty acids and glycerol is expected. Fatty acids will be further used by these organisms as their main source of energy throughout all the different life stages (early development, growth, reproduction, etc.). The supporting BCF/BAF values estimated with the BCFBAF v3.01 program also indicate that the substance has a low bioaccumulation potential.
A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within the CSR.
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