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Diss Factsheets
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EC number: 200-957-6 | CAS number: 76-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- In vivo study conducted in rabbits
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- In vivo methods considered acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methyl-2-nitropropan-1-ol
- EC Number:
- 200-957-6
- EC Name:
- 2-methyl-2-nitropropan-1-ol
- Cas Number:
- 76-39-1
- Molecular formula:
- C4H9NO3
- IUPAC Name:
- 2-methyl-2-nitropropan-1-ol
- Details on test material:
- Purity is above 99%.
Constituent 1
- Specific details on test material used for the study:
- Name of test material (as cited in study report): P-184 or NMP Crystals ( 2-nitro-2-methyl-1-propanol) Lot # C-027907 CAS Number 76-39-1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino; strain not specified
- Details on test animals or tissues and environmental conditions:
- Six albino rabbits weighing 3.0 +/- 0.5 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent negative control
- Amount / concentration applied:
- 0.1 g test material instilled into the lower conjunctival sac of the right eye. The left eye served as an untreated control
- Duration of treatment / exposure:
- Following instillation of test material, the eye lids were held closed for 1-2 seconds to prevent loss of the material. Eyes were examined at 24, 48 and 72 hours post treatment. At 72 hours and on the 7th day a drop of sodium fluororescein (0.24%) was placed in the eye and the excess fluoroscein was flushed with sterile saline (0.85%). The eye was examined under a UV light for corneal lesions.
- Observation period (in vivo):
- 7 days
- Details on study design:
- Following instillation of test material, the eye lids were held closed for 1-2 seconds to prevent loss of the material. Eyes were examined at 24, 48 and 72 hours post treatment. At 72 hours and on the 7th day a drop of sodium fluororescein (0.24%) was placed in the eye and the excess fluoroscein was flushed with sterile saline (0.85%). The eye was examined under a UV light for corneal lesions.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 37.7
- Max. score:
- 42
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 36.8
- Max. score:
- 42
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 36.5
- Max. score:
- 42
- Reversibility:
- not fully reversible within: 7 days
- Irritant / corrosive response data:
- Test material affected the cornea, iris and conjunctiva in all the rabbits. The severity od the lesions were still visible at 72 hours. At 72 hours after the sodium fluroescein treatment the treated eyes of all six rabbots showed corneal scarring and when re-examined on the 7th day they showed little recovery. Test material was determined to be a severe eye irritant.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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