2-methyl-2-nitropropan-1-ol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation / corrosion, other

Remarks:

Study was in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPP 81-5 (Acute Dermal Irritation)

Version / remarks:

Following a four hour exposure sites were visually scored for edema, erythema and tissue destruction at 4, 24 and 48 hours

Deviations:

not applicable

Principles of method if other than guideline:

The skin corrosion potential of the test substance was assessed in rabbits. 0.5 g of the test substance were applied on the shaved back of each animal, which was covered with an occlusive dressing. After 4 hours, the skin area was cleaned and the skin sites were examined for erythema and edema. The skin sites were examined again 24 and 48 hours after exposure.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methyl-2-nitropropan-1-ol

EC Number:

200-957-6

EC Name:

2-methyl-2-nitropropan-1-ol

Cas Number:

76-39-1

Molecular formula:

C4H9NO3

IUPAC Name:

2-methyl-2-nitropropan-1-ol

Details on test material:

Purity is above 99%.

Specific details on test material used for the study:

- Name of test material (as cited in study report): P-184 or NMP Crystals ( 2-nitro-2-methyl-1-propanol) Lot # C-027907 CAS Number 76-39-1

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS: Weight at study initiation: 3.0 ± 0.5 kg

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.5 g powder per site

Duration of treatment / exposure:

4 hours

Observation period:

48 hours

Number of animals:

6

Details on study design:

The skin sites were examined for erythema, edema and tissue destruction 4, 24 and 48 hours after exposure. - Area of exposure: The skin from the back area of each rabbit was shaved free of hair. 0.5 g of the test substance was applied and the back was covered with a fabric patch and occluded with tape. The entire trunk was loosely wrapped with an impervious rubber cloth and by a stainless steel protective screen held in place by tape. Following a 4 hour exposure the patched were removed, the treated sites cleaned and visually examined for erythema, edema and tissue destruction at 4, 24 and 48 hours following exposureSkin reactions of erythema, edema, or tissue destruction was noted and recorded. Any tissue destruction will be scored as a positive reaction (according to Draize, Association of Food and Drug O f f i c i a l s of the United States, p. 48, 1959).

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

48 h

Score:

0

Reversibility:

other: Not applicable

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

48 h

Score:

0

Reversibility:

other: Not applicable

Irritant / corrosive response data:

No erythema, edema or corrosion was reported at any time during the observation period.

Other effects:

No data.

Any other information on results incl. tables

Corrosion results

Irritation parameter	Basis	Time point	Score	Reversibility	Remarks
erythema score	mean (of all 6 animals)	4,24,48 hr	0	other: reversibility not applicable
edema score	mean (of all 6 animals)	4,24,48 ht	0	other: reversibility not applicable

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Not corrosive to the skin.