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EC number: 204-376-9 | CAS number: 120-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
3,4-Dimethoxyphenethylamine (CAS 120-20-7) is acutely harmful to aquatic invertebrates (according to OECD criteria).
Key value for chemical safety assessment
Additional information
QSAR Disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 3,4 -dimethoxyphenethylamine (CAS 120 -20 -7) (Q)SAR results were used for toxicity to aquatic organisms. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, experimental studies on aquatic toxicity are not provided.
The assessment of the short-term toxicity of 3,4 -dimethoxyphenethylamine (CAS 120-20-7) to aquatic invertebrates is based on a read-across approach to the two structurally analogous substances and is supported by estimates from several QSAR model for the target substance itself.
Both compounds were tested on Daphnia magna according OECD 201. A study with 3,4 -dimethoxyphenylacetonitrile (CAS 93-17-4) resulted in a 48-h EC50 of greater than 100 mg/L. All nominal test concentrations were analytically verified (BASF AG, 2003, report no. 02/0651/50/1).
4 -allylveratrole appears to be more toxic with a 48-h EC50 of 38 mg/L (meas.). The data are from a reliable source (NITE, J-CHECK database, Japan). Though no test report is available at present the data from this source are known to be well documented and the test are performed according to GLP and OECD guidelines.
In addition, the short-term toxicity was calculated for the test substance 3,4 -dimethoxyphenethylamine (CAS 120-20-7) with several estimation models. The table below lists the result from the described above OECD studies with the structurally analogous substances 4 -allylveratrole (CAS 93-15-2) and 3,4 -dimethoxyphenylacetonitrile (CAS 93-17-4) and, in addition, the applied (Q)SAR models, the estimated effect toxicity and information on the applicability domain (AD) for the target substance.
The target substance 3,4 -dimethoxyphenethylamine (CAS 120-20-7) is estimated to be acutely harmful to aquatic invertebrates based on the models where the substance was within the applicability domain, except for the model ECOSAR v1.11 (48 -h LC50 = 338 mg/L). According to the VEGA models, the substance would be acutely toxic to aquatic invertebrates. However, the substance was not within the applicability domain.
Following a worst-case assessment, 3,4-Dimethoxyphenethylamine (CAS 120-20-7) is considered to be acutely harmful to aquatic invertebrates.
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