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EC number: 204-376-9 | CAS number: 120-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is with high probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
A 96-h acute toxicity study was conducted according to German Industrial Standard DIN 38412, part 15 which is similar to OECD guideline 203, testing the acute toxicity of 3,4-dimethoxyphenethylamine (CAS 120-20-7) towards Leuciscus idus (BASF SE, 1989, report no. 10F0747/885014). The concentrations were not analytically verified but the test substance is expected to be stable in water due to the high water solubility (miscible, BASF SE, 2017, report no. 16L00555), the low vapor pressure (VP = 0.035 Pa @ 25 °C, BASF AG, 1991, report no. BRU 91.370) and the low Henry's Law Constant (HLC = 0.00029 Pa m³/mol, @ 25 °C, estimated, BASF SE, 2017).
Without pH-adjustment, the 96-h LC50 was 68.1 mg/L (geometric mean of LC0 and LC100). While no effect was observed in test solutions of 100 mg/L with pH-adjustment which was tested in parallel.
The acceptable pH-range of the test medium for fish is pH 6.0 to 8.5 according to OECD 203. Thus, the mortality in the non-neutralized test solutions is considered to be caused by pH (100 mg/L, without pH-adjustment: initial pH = 9.2). Therefore, the LC50 is higher than 100 mg/L at environmentally relevant pH values.
As this test was performed with the 3,4-dimethoxyphenethylamine (CAS 120-20-7) itself and is of sufficient reliability, this study was selected as key study for the assessment of the acute toxicity to fish.
As read-across has been performed with two structurally similar substances, the available information is listed here. However, in case of 4-allylveratrole (CAS 93-15-2), the effect values deviate strongly from the target substance. As information on the test conditions are limited and no information is available on pH etc., these results should not be considered for the assessment of short-term effects of the target substance to fish.
The acute toxicity of the source chemical 3,4-Dimethoxyphenylacetonitrile (CAS 93-17-4) was studied according the German Industrial Standard DIN 38412, part 15. Test concentrations were not analytically verified. The exposure conditions were static. The 96-h LC50 was greater than 100 mg/L (nominal; 40% mortality at 100 mg/L).
Effect values for 4-allylveratrole (CAS 93-15-2) are available for three fish species. NITE published a 96-h LC50 of 14 mg/L (measured). The test was performed in 2003 according to OECD 203 and GLP. The test concentrations were analytically verified. Further results are available from a review report by Environment Canada (2010). The result was originally published in 1975. The 96-h LC50 for Oncorhynchus mykiss was determined to be 6 mg/L (nominal). The 96-h LC50 for Lepomis macrochirus is 8.1 mg/L (nominal). The results for O. mykiss and L. macrochirus should be disregarded as in a worst-case assessment, the maximum solvent concentration (OECD 203: <=100 mg/L) was exceeded by a factor of 10 (stock solution of 1% and 10% test material dissolved in acetone; max. test concentration: 10 mg/L; max. acetone concentration: 1000 mg/L).
Based on the available information from the target substance at the environmentally relevant conditions, 3,4-dimethoxyphenethylamine is with high probability acutely not harmful to fish.
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