Registration Dossier
Registration Dossier
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EC number: 700-585-9 | CAS number: 35786-94-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP Study, but sufficiently documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 11 000 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LDLo
- Effect level:
- ca. 11 000 mg/kg bw
Any other information on results incl. tables
The test item was administered as a single oral dose by intragastric intubation to male rats at doses of 670, 2300, 3400, 5000, 7500, or 11,000 mg/kg. Following dosing, the rats were weighed and observed for mortality and clinical signs of toxicity over a 14-day observation period. No deaths occurred. The rats dosed at 670, 2300, 3400, or 7500 mg/kg exhibited no clinical
signs of toxicity or body weight loss during the study. The rat dosed at 5000 mg/kg exhibited lung noise on the day of dosing and yellow-stained perineum up to 4 days after dosing. Low posture, brown oral discharge, partially closed eyes, lethargy, lung noise, and yellow-stained perineum were observed by 4 days after dosing in the rat dosed at 11,000 mg/kg. Body weight
loss of approximately 15 or 21% of initial weight occurred by 3 or 4 days after dosing in the rats
dosed at 5000 or 11,000 mg/kg.
Under the conditions of this study, the oral ALD for the test item was greater than 11,000 mg/kg of
body weight. This substance is considered to be very low in toxicity (ALD greater than
5000 mg/kg) when administered as a single oral dose to male rats.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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