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EC number: 807-715-4 | CAS number: 1354569-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There are two valid experimental studies conducted on acute aquatic toxicity, even if the extremely limited water solubility of the test substance is taken into account.
The algal toxicity test conducted according to OECD 201 and EC C.3 under GLP indicates that the test substance exhibited no toxic effects at the saturation concentration. The reported 72 h EC50 values are > 100 % (v/v) and statistically determined NOECs based on growth inhibition and yield were 100 % v/v saturated nominal concentration (p >= 0.05). In addition, the OECD Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures (OECD 2000) was followed and two preparatory tests conducted prior to the definitive test. Also the concentrations were analytically determined in the test solution at the beginning and end of the definitive test. As all validation criteria were met, the test result is considered as reliable (Klimisch 1). The study is selected as the key on acute aquatic toxicity.
In daphnids, the experimentally observed acute aquatic toxicity (EC50 48-h) was > 100% of the saturated solution in a non-GLP screening test (OECD 202). The nominal concentrations were 0.1, 1, 10 and 100 mg/L at 20 oC. Concentrations were not analytically measured and the substance is very poorly soluble in water. The results are therefore rated as reliable with restrictions (Klimisch 2). The experimental screening study is selected as a supporting.
An ECOSAR v 1.1 QSAR modelling was performed using experimentally determined water solubility and log P values. The model gave five estimates (i - v) for three classes: esters, methacrylates and neutral organics (baseline toxicity).The methacrylate estimates for five endpoints were selected to be reported in this dataset as the most conservative, but disregarded as not reliable (Klimisch 3) due to the applicability domain of the acute toxicity estimates and and limited chronic data:
i) The ECOSAR QSAR estimate for acute aquatic toxicity LC50 (96 h) on fish was 0.007 mg/L based on mortality. As the experimental Log P (7.63) used for modelling is out of applicability domain of the model (maximum 5.0 for fish acute toxicity), the result is rated as not reliable (Klimisch 3).
ii) The ECOSAR QSAR estimate for acute aquatic toxicity LC50 (48 h) on daphnids was 0.007 mg/L based on mortality. As the experimental Log P (7.63) used for modelling is out of applicability domain of the model (maximum 5.0), and the data set is very limited, the result is rated as not reliable (Klimisch 3).
iii) The most conservative ECOSAR QSAR estimate for chronic toxicity ChV of methacrylates on fish was 0.000418 mg/L based on acute/chronic ratio 1/10. Even if log P of the test substance 7.63 is within the applicability domain of the chronic model (< 8), the estimate is derived from acute fish toxicity results, where the log P is out of the descriptor domain. The result is therefore rated as not reliable (Klimisch 3).
iv) The most conservative ECOSAR QSAR estimate for chronic toxicity ChV of methacrylates on daphnids was 0.000943 mg/L based on acute/chronic ratio 1/10. Even if log P of the test substance 7.63 is within the applicability domain of the chronic model (< 8), the estimate is derived from acute fish toxicity results, where the log P is out of the descriptor domain. The result is therefore rated as not reliable (Klimisch 3).
v) The ECOSAR QSAR estimates for acute aquatic toxicity EC50 (96 h) on green algae was 0.0018 mg/L, and for chronic toxicity ChV was 0.01 mg/L. As there are extremely limited acute and chronic toxicity data on algae, the result is rated as not reliable. Furthermore, log P of the test substance 7.63 is out of the domain of the acute descriptors (maximum 5). The results are therefore rated as not reliable (Klimisch 3).
Conclusion: the two experimental acute toxicity tests conducted on algae and daphnids both indicate that the test substance is not acutely toxic to daphnids and algae at saturation (76 h and 24 h EC50 values > 100 % v/v saturated nominal concentration). For algae, the derived chronic NOEC value is also 100 % v/v saturated nominal concentration, indicating that there are no chronically toxic effects at the saturation concentration. The ECOSAR 1.1 QSAR modelling results are disregarded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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