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Diss Factsheets
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EC number: 807-715-4 | CAS number: 1354569-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Bis (2 -ethylhexyl)citraconate is not hydrolysable (modelled half-life at pH 7 was 49 years; HYDROWIN 2.00). The result was used as weight of evidence for classification and labelling and PBT assessment.
The test substance bis(2 -ethylhexyl)citraconate is assessed as not readily biodegradable for classification and labelling based on a screening non-GLP OECD 301 D Test. Therein the substance was observed not to inhibit growth of micro-organisms at 2.3 mg/L nominal concentration. The available QSAR models BIOWIN 4.10 and STPWIN however provide some weight of evidence of ultimate biodegradability, for which no valid experimental test result is available. The BIOWIN model is however assessed to overpredict biodegradability of structurally analogous compounds. This conclusion is used as weight of evidence for PBT assessment.
The estimated bioconcentration factor was 1655 L/kg wet-wt by a BCF regression model based on log P (BCFBAF 3.01). However, as the whole-body primary biotransformation half-life rate estimate for fish was 0.43 d ("normalized” for a 10 g fish at 15ºC by the Arnot 2008 model of BCFBAF 3.01), biotransformation is expeted to prevent bioaccumulation in the food chain. A more detailed three trophic tier modelling (Arnot-Gobas 2003 of BCFBAF 3.01) result of support the conclusion. The results are used as weight of evidence in PBT assessment.
Bis(2 -ethylhexyl)citraconate has high adsorption tendency to organic carbon (estimated log Koc 4.6 by KOCWIN 2.00), and very low volatity from aqueous environment to the atmosphere (estimated Henry's coefficient 0.000013 atm m3/mol at 25oC and 101.3 kPa by HENRYWIN 3.2).
There is weight of evidence from eight QSAR models (EPA PBT Profiler 2.0 and MacKay Level III Fugacity Model of EPISuite
4.11) that when released to the environment, the test substance is mainly distributing to soil and sediment compartments, where it is biodedegraded in days or weeks. In addition, the modelled bioconcentration factor was 630 by the EPA PBT profiler 2.0.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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