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EC number: 299-370-6 | CAS number: 93859-32-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- A Pharmacological Study of Sodium Alkyl a Homologous Sulfates
- Author:
- LAURENCE E. GALES and PAUL M. SCOTT
- Year:
- 1 953
- Bibliographic source:
- Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 283, 1953
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of Sodium octyl sulfate in rats
- GLP compliance:
- not specified
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- Sodium octyl sulphate
- EC Number:
- 205-535-5
- EC Name:
- Sodium octyl sulphate
- Cas Number:
- 142-31-4
- IUPAC Name:
- sodium octyl sulfate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report):Sodium octyl sulfate - Molecular formula (if other than submission substance):C8H18O4S.Na- Molecular weight (if other than submission substance):232.274 g/mole - Substance type:Organic - Physical state:Crystals (Solid)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: No data available - Age at study initiation: No data available- Weight at study initiation: No data available - Fasting period before study: No data available - Housing: No data available - Diet (e.g. ad libitum): Rat pellets experimental diet. - Water (e.g. ad libitum): No data available - Acclimation period: No data available ENVIRONMENTAL CONDITIONS- Temperature (°C): 21.11 °C- Humidity (%): Constant - Air changes (per hr): No data available - Photoperiod (hrs dark / hrs light): No data available IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Distilled
- Details on oral exposure:
- VEHICLE- Concentration in vehicle: 3200 mg/kg bw - Amount of vehicle (if gavage): 1 cc / 100 g bw- Justification for choice of vehicle: No data available- Lot/batch no. (if required): No data available- Purity: No data available MAXIMUM DOSE VOLUME APPLIED: No data available DOSAGE PREPARATION (if unusual): A dosage schedule was established whereby each group of five animals was given a dosage which differed by 0.5 g/Kg. from each preceding or succeeding dosage. The compounds were administered as aqueous mixtures prepared in such a manner that 1 cc. of detergent preparation was administered for each 100 g. of rat. The mixtures administered were warmed to 350. However, the viscosity of the mixtures of tetradecyl, hexadecyl, and octadecyl compounds at dosages greater than 3.5 g/Kg. for the first preparation and 3.0 g/Kg. for the latter two preparations was so high that the mixtures could not be forced through an oral needle.CLASS METHOD (if applicable)- Rationale for the selection of the starting dose: No data available
- Doses:
- 3200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 24 hours - Frequency of observations and weighing: No data available - Necropsy of survivors performed: yes- Other examinations performed: clinical signs, gross pathology and histopathology were examined.
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed in treated rats as compared to control.
- Clinical signs:
- other: Depression, severe diarrhea which was characterized by the presence of Blood was observed in treated rats as compared to control.
- Gross pathology:
- Varying stages of acute gastritis and congestion of the mucosa of small intestine, stomach contained some food, swollen and severely ulcerated was observed in treated rats as compared to control.
- Other findings:
- Histopathology: Presence of crenated and ruptured red blood cells along with accumulations of cells from the gastric mucosa was observed in treated rats as compared to control.
Any other information on results incl. tables
Oral Ld50 Results for the Sodium alkyl sulpates determined for Rats
Sodium alkyl sulpates | Oral Administration | |
Octyl | pH of solution | LD50 for rats Gm./Kg |
| 6.8 | 3.20 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be 3200 mg/kg bw when rats was treated with Sodium octyl sulfate orally by gavage in distilled water.
- Executive summary:
In a acute oral toxicity study,rats was treated withSodium octyl sulfate in the concentration of 3200 mg/kg bw orally by gavage in distilled water. 50 % mortality and Depression, severe diarrhea which was characterized by the presence of Blood was observed in treated rats as compared to control. In addition, Varying stages of acute gastritis and congestion of the mucosa of small intestine, stomach contained some food, swollen and severely ulcerated and Presence of crenated and ruptured red blood cells along with accumulations of cells from the gastric mucosa was observed in treated rats as compared to control. Therefore,LD50 was considered to be 3200 mg/kg bw when rats was treated withSodium octyl sulfate orally by gavage in distilled water.
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