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Diss Factsheets
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EC number: 607-233-2 | CAS number: 2343-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.006 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.061 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 10 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no exposure of sediment expected
Sediment (marine water)
- Hazard assessment conclusion:
- no exposure of sediment expected
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Toxicity studies in fish, invertebrates and algae have been conducted for 2-propenoic acid, 2-fluoro, methyl ester and it was concluded that fish are the most sensitive organisms based on the available studies. A reliable short-term toxicity study with fish is available for 2-propenoic acid, 2-fluoro, methyl ester with a 96-hour LC50 of 6.1 mg/L. This value is the basis for the freshwater PNEC with an assessment factor of 1000 applied to account for potential intra- and interspecific variation, the use of short-term aquatic data and other general uncertainties, such as laboratory to field extrapolation. The microbial study is waived due to significant losses of test substance due to volatilisation under the test conditions making it not technically feasible to conduct this study.
In accordance with Annex X of the Regulation (EC) No 1907/2006 REACH concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), information regarding long-term sediment and soil toxicity tests need not be conducted unless the chemical safety assessment indicates the need to further assess the effects of the substance to these organisms. The substances low potential to adsorb or partition to soil and sediment is demonstrated by the low Koc (<1.25) and very low log octanol-water partition coefficient (Log Kow) of 0.931. In addition, the substance is likely to undergo rapid abiotic degradation and some biodegradation. It is concluded that direct or indirect exposure of sediments and soils is unlikely and further testing is not required.
Conclusion on classification
2 -Propenoic acid, 2-fluoro, methyl ester is not classified as a persistent, bioaccumulative or toxic (PBT) substance. Based on available reliable data for toxicity of 2-propenoic acid, 2-fluoro, methyl ester, short-term acute toxicity (LC50 or EC50) to aquatic organisms is >0.01 mg/L and does not meet the definitive toxicity criterion according to the ECHA guidance on PBT assessment (Part C). Therefore, it is concluded that the substance does not fulfill the toxicity (T) criterion as laid down in Annex XIII of Regulation (EC) No 1907/2006.
Based on a reliable hydrolysis study, 2-propenoic acid, 2-fluoro, methyl ester does not meet the criteria for Persistence (P) as the half-life is < 40 days in freshwater. The measured Log Kow is less than 4.5 and it is concluded that there is a low potential for exposure and bioaccumulation in aquatic and terrestrial organisms. 2-propenoic acid, 2-fluoro, methyl ester does not fulfill the criteria “bioaccumulative (B)” or “very bioaccumulative (vB)”. The overall conclusion is that 2-propenoic acid, 2-fluoro, methyl ester, is not considered a PBT or vPvB substance. No further testing is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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