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EC number: 700-903-6 | CAS number: 255830-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Non-quantitative study of effect of increasing concentration of test substance on the sewage treatment process
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- activated sludge
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 30 d
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- other: sewage gas production volume
- Duration:
- 30 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- not specified
- Basis for effect:
- other: sewage gas volume reduced and fermentation delayed
- Details on results:
- At 50 mg/L the test material showed no effects.
At 100 and 200 mg/L the start of fermentation was delayed, but constant gas volume was achieved in the same period as in the control.
At 500 mg/L the test material , the system was strongly disturbed, as indicated by a late beginning of fermentation, and greatly reduced sewage gas production volume. - Conclusions:
- A non-standard study of effects on sewage treatment plant micro-organisms was conducted according to generally accepted scientific principles but lacks detail in the study report. The result of a lack of effects on respiration up to 200 mg/L provides reliable evidence.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Results determined in Sapromat test, derived from comparison of biochemical oxygen demand
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- activated sludge
- Details on inoculum:
- Klaeranlage-Muenchen-Grosslappen
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 5 d
- Remarks on exposure duration:
- Whilst the exposure duration is not explicitly stated, BOD5 values are quoted and so it is deduced that the exposure period is at least 5 days duration.
- Post exposure observation period:
- Not reported
- Hardness:
- Not reported
- Test temperature:
- Not reported
- pH:
- Not reported
- Dissolved oxygen:
- Not reported
- Salinity:
- Not reported
- Nominal and measured concentrations:
- Not reported
- Details on test conditions:
- Test concentration series: 1, 5, 10, 50 and 100 mg/L
- Reference substance (positive control):
- no
- Duration:
- 5 d
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- A non-standard study of activated sludge respiration inhibition determined that the top concentration of 100 mg/L did not cause inhibition. The result is considered reliable.
Referenceopen allclose all
Description of key information
EC0 200 mg/l activated sludge respiration inhibition (non-standard test, rel. 2) Henkel 1972. The data are read across from the parent acid ATMP.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 200 mg/L
Additional information
A number of non-standard studies are available providing evidence that ATMP has no inhibitory effect on micro-organisms at concentrations up to ca. 200 mg/L.
A study of seven Swiss WWTPs in 1996 shows a maximum concentration of ATMP in WWTP untreated influent of ca. 0.8 µmol/L, equivalent to ca. 0.26 mg/L.
The data set is further supported by the findings of an activated sludge respiration inhibition test conducted with an ammonium salt of ATMP (Worth and Mead, 1995). In this reliable study conducted in accordance with OECD Test Guideline 209, an EC50 >1000 mg/l was determined based on a 3-hour exposure period.
ATMP-H (CAS 6419-19-8) has three methylphosphonate groups connected by a central tertiary amine nitrogen. ATMP-N-oxide-H (15834-10-3) has a directly analogous chemical structure with a central tertiary amine N-oxide group.
As well as being structural analogues, both phosphonates have consistent chemical properties including moderate MW (299 and 315 respectively), very low log Kow(-3.53 and ≤-4respectively) and are highly soluble in water. The substances generally possess similar physico-chemical properties and are expected not to be readily biodegradable in the environment.Information about tertiary amine N-oxides suggests that read across of effects data from the amine to the N-oxide is valid and precautionary.
Both acid and certain salt forms of these phosphonates behave no differently from each other and are fully dissociated in dilute aqueous conditions of defined pH, when presented at identical concentrations. In environmental fate and ecotoxicity studies, the local pH and ionic conditions within the environment dominate the speciation of the phosphonate, irrespective of the form originally added. At a defined pH, a salt will behave no differently to the parent acid, at identical concentration of the speciated form present, and will be fully dissociated to yield acid and counter-ion.
The read-across justification is attached in IUCLID Section 13.
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