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EC number: 215-236-1 | CAS number: 1314-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
TOXICITY TO FISH
Short-term toxicity to fish
The acute toxicity of the test itemPhosphorpentoxid(batch no.:DEH2018965)to fish (zebrafish) was determined according to OECD-Guideline for Testing of Chemicals No. 203 (1992) from2009-12-14 to 2009-12-18atDr.U.Noack-Laboratorien, 31157 Sarstedt , Germany. A static test with 5 test concentrations 10 – 18 – 32 – 56 - 100 mg/L (factor 1.78) and for pH-control an additional replicate of the highest concentration with correction of the pH-value was performed. Duration of the test was 96 h. 7 test organisms were exposed to each test concentration and control. Water quality parameters pH-value, temperature and oxygen-saturation measured after 0, 24, 48, 72 and 96 h were determined to be within the acceptable limits. The concentrations of the test itemPhosphorpentoxidwere analysed via standardized photometric test at all concentration levels at test start and test end. Recovery rates ofPhosphorpentoxidat the beginning of the study were in the range of 80 - 98 % and at the end in the range of 49 – 100 % of the nominal values. For details of the analytical results please refer to part 9. At the test item concentration of 56 and 100 mg/LPhosphorpentoxidcaused pH-related lethal effects whereas a concentration of 100 mg/L with adjustment of the pH-value to 6.97 did not cause any effects. All effect levels are given based on nominal concentrations of the test itemPhosphorpentoxid.
LC-Values with 95 % Confidence Intervals
(based on nominal test item concentrations)
ValueswithAdjustment of pH |
ValueswithoutAdjustment of pH |
|||
Test duration [h] |
LC50 |
p = 95 % [mg/L] |
LC50 |
p = 95 % [mg/L] |
24 |
> 100 |
n. a. |
42 |
32 - 56 * |
48 |
> 100 |
n. a. |
42 |
32 - 56 * |
72 |
> 100 |
n. a. |
42 |
32 - 56 * |
96 |
> 100 |
n. a. |
42 |
32 - 56 * |
LC100= |
> 100 |
56 |
||
Lowest test item concentration |
||||
with 100 % mortality after 96 h |
||||
LC0= |
100 |
32 |
||
Highest test item concentration |
||||
with 0 % mortality after 96 h |
||||
NOEC (0-96 h) = No observed effect concentration |
100 |
32 |
Long-term toxicity to fish
Diphosphorus pentaoxide is hygroscopic forming with water an aqueous solution of phosphorus oxyacids (primary hydrolysis) which are subject to further (secondary) hydrolysis to the end product phosphoric acid, H3PO4.
Hydrolysis of P2O5 in water under conditions relevant for ecotoxicological studies (100mg/L, 25°C) leads to slightly acidic solutions(pH 3.6) with the main product of tetraphosphoric acid. Further hydrolysis within the time frame of ecotoxicological studies is insignificant.
Under environmental conditions the hydrolysis products are available as different phosphate (Na, K, Ca). Phosphate and phosphorus are an essential nutrient of microorganisms, plants and animals. Phosphoric acid is readily utilizable by aquatic plants and microorganisms. Phosphorus compounds are an important component of living matter and all organisms contain a certain quantity.
Short-term toxicity tests are available according Annex VII, Column 1, 9.1.1 and 9.1.2 and according Annex VIII, Column 1, 9.1.3 and 9.1.4. The chemical safety assessment according Annex I does not indicate the need to investigate further the effects on aquatic organisms. Based on the results of the short-term toxicity tests long-term toxicity tests are not warranted.
TOXICITY TO DAPHNIA
Short-term toxicity to aquatic invertebrates
The acute immobilization of the
test item Phosphorpentoxid (batch number: DEH2 018965) toDaphnia
magna(STRAUS) was determined according toOECD
202 (2004)from 2010-02-03 to 2010-02-05 atDr.U.Noack-Laboratorien,
Käthe-Paulus-Str. 1, D-31157 Sarstedt, Germany.
The study was conducted with 5 nominal test item concentrations ranging
from 6.25 to 100 mg/L set up in a geometric series with a dilution
factor of 2 under static conditions over a period of 48 h.
Additionally a pH control was tested. 20 test organisms were exposed
to each test concentration and control.
The
phosphate content as a component of the test itemPhosphorpentoxidwas
analysed viaUV-spectrophotometrywith
a pipette test at all test item concentrations, the pH control and
the control after 0 h and 48 h. Details of the analytical method are
given in part10.The
recovery rates in the fresh (0 h) and old media (48 h) of the tested
concentration levels were in the range of 86 % to 98 %of
the nominal values.All
effect values are given based on the nominal concentrations of the
test item Phosphorpentoxid.Phosphorpentoxid only caused a pH-related
toxic effect at the concentration level 100 mg/L whereas a
concentration of 100 mg/L with adjustment of the pH-value from 3.32
to 7.03 did not cause any effects.
Water
quality parameters (pH-value and dissolved oxygen concentration),
measured at 0 h and 48 h, were determined to be within the
acceptable limits. The validity criteria of the test guideline were
fulfilled.
Table1: EC10-, EC50- (with Confidence Interval), EC100- Values, NOEC and LOEC
(based on the nominal concentrations of the test itemPhosphorpentoxid)
ValueswithAdjustment of pH |
ValueswithoutAdjustment of pH |
||
Test Duration |
Nominal Concentration of the Test Item |
||
EC10 |
24 |
> 100 |
Not applicable |
48 |
> 100 |
Not applicable |
|
EC50 with 95 % confidence limits (Cl) |
24 |
> 100 (Cl: Not applicable) |
70.7 (Cl: 50.0 – 100) |
48 |
> 100 (Cl: Not applicable) |
70.7 (Cl: 50.0 – 100) |
|
EC100 |
24 |
> 100 |
100 |
48 |
> 100 |
100 |
|
NOEC |
48 |
100 |
50.0 |
LOEC |
48 |
> 100 |
100 |
Long-term toxicity to aquatic invertebrates
Diphosphorus pentaoxide is hygroscopic forming with water an aqueous solution of phosphorus oxyacids (primary hydrolysis) which are subject to further (secondary) hydrolysis to the end product phosphoric acid, H3PO4.
Hydrolysis of P2O5 in water under conditions relevant for ecotoxicological studies (100mg/L, 25°C) leads to slightly acidic solutions(pH 3.6) with the main product of tetraphosphoric acid. Further hydrolysis within the time frame of ecotoxicological studies is insignificant.
Under environmental conditions the hydrolysis products are available as different phosphate (Na, K, Ca). Phosphate and phosphorus are an essential nutrient of microorganisms, plants and animals. Phosphoric acid is readily utilizable by aquatic plants and microorganisms. Phosphorus compounds are an important component of living matter and all organisms contain a certain quantity.
Short-term toxicity tests are available according Annex VII, Column 1, 9.1.1 and 9.1.2 and according Annex VIII, Column 1, 9.1.3 and 9.1.4. The chemical safety assessment according Annex I does not indicate the need to investigate further the effects on aquatic organisms. Based on the results of the short-term toxicity tests long-term toxicity tests are not warranted.
TOXICITY TO ALGAE
The toxicity ofPhosphorpentoxid(batch number DEH2018965)to the unicellular freshwater green algaDesmodesmus subspicatuswas determined according to the principles of OECD 201atDr.U.Noack-Laboratorienin 31157 Sarstedt, Germanyfrom February 9thto July 2ndwith the definitive exposure phase from June 29thto July 2nd, 2010.The aim of the study was to assess the effects on growth rate and yield over a period of 72 h.
The study was conducted under static conditions with an initial cell density of approximately 2 – 5 x 103cells/mL. Five concentration levels were tested in a geometrical series with a dilution factor of 2, nominal: 12.5 - 25.0 - 50.0 - 100 - 200 mg/L.In order to exclude possible effects due to the pH-value all test concentrations were tested by correction of the pH-value.Three replicates were tested for each test item concentration and six replicates for the control.Environmental conditionswere determined to be within the acceptable limits.
The concentrations ofPhosphorpentoxidwereanalysed at all concentration levels after 0 and 72 h via standardized photometric test. The measured concentrations ofPhosphorpentoxidat test start were in the range of 89 – 93 % of the nominal values.At the end of the testPhosphorpentoxidgave recoveries of 79 – 97 % of the nominal values.All effect values are given based on nominal concentrations of the test item.
NOEC, LOEC, EC - values and 95 % Confidence Intervals of Phosphorpentoxid(0-72 h)
based on nominal test item concentrations [mg/L]
Rate-related Inhibition |
|
NOEC |
25.0 |
LOEC |
50.0 |
ErC10 |
39.4 (37.2 – 41.5) |
ErC20 |
48.6 (47.3 – 50.0) |
ErC50 |
66.5 (64.0 – 69.7) |
Inhibition of Yield |
|
NOEC |
12.5 |
LOEC |
12.5 |
EyC10 |
12.5 |
EyC20 |
16.3 ( 12.5 – 22.8) |
EyC50 |
38.0 (34.2 – 41.2) |
The toxicity ofPhosphorpentoxid(batch number DEH2018965)to the unicellular freshwater green algaDesmodesmus subspicatuswas determined according to the principles of OECD 201atDr.U.Noack-Laboratorienin 31157 Sarstedt, Germanyfrom February 9thto July 2ndwith the definitive exposure phase from June 29thto July 2nd, 2010.The aim of the study was to assess the effects on growth rate and yield over a period of 72 h.
The study was conducted under static conditions with an initial cell density of approximately 2 – 5 x 103cells/mL. Five concentration levels were tested in a geometrical series with a dilution factor of 2, nominal: 12.5 - 25.0 - 50.0 - 100 - 200 mg/L.In order to exclude possible effects due to the pH-value all test concentrations were tested by correction of the pH-value.Three replicates were tested for each test item concentration and six replicates for the control.Environmental conditionswere determined to be within the acceptable limits.
The concentrations ofPhosphorpentoxidwereanalysed at all concentration levels after 0 and 72 h via standardized photometric test. The measured concentrations ofPhosphorpentoxidat test start were in the range of 89 – 93 % of the nominal values.At the end of the testPhosphorpentoxidgave recoveries of 79 – 97 % of the nominal values.All effect values are given based on nominal concentrations of the test item.
NOEC, LOEC, EC - values and 95 % Confidence Intervals of Phosphorpentoxid(0-72 h)
based on nominal test item concentrations [mg/L]
Rate-related Inhibition |
|
NOEC |
25.0 |
LOEC |
50.0 |
ErC10 |
39.4 (37.2 – 41.5) |
ErC20 |
48.6 (47.3 – 50.0) |
ErC50 |
66.5 (64.0 – 69.7) |
Inhibition of Yield |
|
NOEC |
12.5 |
LOEC |
12.5 |
EyC10 |
12.5 |
EyC20 |
16.3 ( 12.5 – 22.8) |
EyC50 |
38.0 (34.2 – 41.2) |
TOXICITY TO MICROORGANISMS
A Respiration Inhibition Test according to OECD Guideline No. 209 was performed with the test item Phosphorpentoxid (batch-no. DEH2 018965) on 2010-01-07 atDr.U.Noack-Laboratorien, D-31157Sarstedt.Test system was activated sludge of the municipal treatment plant of D-31157 Sarstedt. The test was performed under static conditions with the nominal concentrations 100 - 180 - 320 - 580 - 1000 mg/L without adjustment of pH and 320 - 580 - 1000 mg/L adjusted to pH 7 to differentiate between pH effects and test item effects. The respiration rates of control, reference and test item concentrations were measured after a contact time of three hours, and the inhibitory effects of the test and reference item were determined in comparison to the control respiration rates. The inhibition of the test item ranged from 15 % to 100 %. The neutralised test item concentrations showed inhibitions from 10 % to 44 %. The EC20-, EC50- and EC80-values were calculated by sigmoidal dose-response regression for the test item concentrations without adjustment of pH and by probit analysis for the test item concentrations adjusted to pH 7.
Table 1: EC-Values with Confidence Interval of Phosphorpentoxid
Valueswithoutadjustment of pH |
Valueswithadjustment of pH |
|||
EC-values |
Confidence interval |
EC-values |
Confidence interval |
|
[mg/L] |
P = 95 [%] [mg/L] |
[mg/L] |
P = 95 [%] [mg/L] |
|
EC20 |
147 |
- |
524 |
- |
EC50 |
215 |
209 - 220 |
>1000 |
>1000 |
EC80 |
275 |
- |
>1000 |
- |
In order to check the activity of the test system and the test conditions a reference test was carried out with copper (II) sulphate pentahydrate as reference item and the reference toxicity was determined. The EC50-value for the reference item was 101 mg/L.
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