Registration Dossier
Registration Dossier
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EC number: 235-715-9 | CAS number: 12607-70-4
Endpoint summary
Administrative data
Description of key information
Nickel carbonate hydroxide is classified according to Annex I to Directive 67/548/EEC with Xn; R 20/22
Key value for chemical safety assessment
Additional information
Oral:
There is one acute oral LD50 study for nickel carbonate which gives values of 625 mg Ni/kg for male rats and 402 mg Ni/kg for female rats (approximately 1263 and 812 mg nickel carbonate/kg). Based on the measured value, classification of nickel carbonate hydroxide as Xn; R22 (GHS: Acute Tox. 4) is justified. This reflects the differences in water solubility of the carbonate (mg/l) compared to the soluble nickel salts (>100 g/l) (EU C&L Dossier and the OECD SIDS draft 2007).
Inhalation:
There is no data available for the acute inhalation toxicity of nickel carbonate and -hydroxide.Absorption of soluble nickel salts following inhalation is considerably greater than after oral
administration. The absorption of less soluble salts is less. A value of 100% absorption has
been agreed for the risk assessment, based on the Industry derogation statement to a “worst case”
comparison. Based on the proposal to classify the substance for acute oral toxicity,
classification for acute inhalational toxicity (R-20) is considered appropriate (GHS: Acute Tox. 4) (EU C&L Dossier and the OECD SIDS draft 2007).
Dermal:
There is no data available for the acute dermal toxicity of nickel carbonate and -hydroxide. In the view of the poor absorption by this route acute toxicity is expected to be low (EU C&L Dossier and the OECD SIDS draft 2007).
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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