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EC number: 231-977-3 | CAS number: 7783-06-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract quoted in a peer review from US EPA.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- TOXICOLOGICAL REVIEW OF HYDROGEN SULFIDE (CAS No. 7783-06-4). In Support of Summary Information on the Integrated Risk Information System (IRIS)
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 003
- Bibliographic source:
- EPA/635/R-03/005. www.epa.gov/iris
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
- Principles of method if other than guideline:
- Assessment of the effect of H2S on spermatogenesis
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Hydrogen sulphide
- EC Number:
- 231-977-3
- EC Name:
- Hydrogen sulphide
- Cas Number:
- 7783-06-4
- Molecular formula:
- H2S
- IUPAC Name:
- hydrogen sulfide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: gas
- Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- 3 hr/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
220 ppm (306 mg/m3)
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- Following the last exposure, each male was caged with two unexposed virgin females for 10 consecutive weeks. Four male rats were administered triethylenemelamine and used as positive controls. The females were sacrificed after 18 days cohabitation. Parameters evaluated included fertility, corpora lutea, total implants, and dead implants.
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- >= 220 ppm
- Sex:
- male
Observed effects
Applicant's summary and conclusion
- Executive summary:
The effect of H2S on spermatogenesis in the rat was assessed by Andrew et al. (1980). A group of 10 14-week-old male Wistar rats were exposed to 220 ppm (306 mg/m3) H2S for 3 hr/day for 7 days, compared to a control or nonexposed group. Following the last exposure, each male was caged with two unexposed virgin females for 10 consecutive weeks. Four male rats were administered triethylenemelamine and used as positive controls. The females were sacrificed after 18 days cohabitation. Parameters evaluated included fertility, corpora lutea, total implants, and dead implants. There were no adverse effects of exposure on these parameters.
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