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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/12/2008 to 17/02/2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in accordance with recognised guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -2.93
- Temp.:
- 22.7 °C
- pH:
- ca. 7
- Details on results:
- No test material was detected in any of the organic phase samples; therefore, the sample responses were considered to be lower than the limit of detection (LOD), considered as the lowest total area noted for the linearity standard of lowest concentration. This would give a worst case scenario for the partition coefficient endpoint.
The analytical method was based on a method supplied by the Sponsor; the complex chromatographic profile was considered to be due to the complex nature of the test material.
Substances having a log10 Pow of greater than 3 are regarded as having the potential to bioaccumulate in the environment.
It is evident from the information obtained in the hydrolysis test and data relating to the pH of the test material in water that negligible hydrolysis of the sample solutions occurred during the course of the partition coefficient test.
The test was carried out at a pH of approximately 7, as recommended for salts (except for Sample 5); However, the effect of pH was considered to be negligible as the dissociation constants of the test material would ensure that it was in an ionised state across the entire environmentally relevant pH range.
Any other information on results incl. tables
HPLC results:
Organic Phase: The linearity of the detector response with respect to concentration was assessed over the concentration range of 0 to 1.01 x 103mg/l. This was satisfactory with a correlation coefficient of 1.000 being obtained.
Aqueous Phase: The linearity of the detector response with respect to concentration was assessed over the concentration range of 0 to 1.02 x 103mg/l. This was satisfactory with a correlation coefficient of 1.000 being obtained.
The definitive test results indicated that virtually all of the test material remained in the aqueous phases, and all of the test material used in the samples was fully recovered. Thus, it was decided that recovery of analysis for the organic phase extraction procedure was not required.
The partition coefficient determined for each sample is shown in the following table:
Sample Number |
Organic/Aqueous VolumeRatio |
Partition Coefficient |
Log10, Pow |
Mean Partition Coefficient |
1 |
10:1 |
<1.48x10-3 <1.49x10-3 |
<-2.83 <-2.83 |
<1.49x10-3 |
|
||||
2 |
||||
3 |
40:1 |
<1.42x10-3 <1.39x10-3 |
<-2.85 <-2.86 |
<1.42x10-3 |
|
||||
4 |
||||
5 |
20:1 |
<1.49x10-3 <1.44x10-3 |
< -2.85 <-2.84 |
<1.44x10-3 |
|
||||
6 |
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test material has been determined to be < 1.49 x 10E-3 at 22.7 ºC, log10 Pow <-2.83.
- Executive summary:
In a determination of general physico-chemical properties study (Harlan project number: 0959/0224) the test material is shown to have a partition coefficient of less than 1.49 x 10-3at 22.7 ± 1.0°C, log10Pow< -2.83.
The determination was carried out using the shake-flask method, Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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