Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 205-443-5 | CAS number: 140-93-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- Estimation
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other: (Q)SAR model
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Principles of method if other than guideline:
- Skin Sensitization Test compatible with OECD429 guidance.The final conclusion is a conclusion made by the reviewer, taking into account all the available evidence, including the in-silico and available experimental results.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium isopropyl xanthate
- IUPAC Name:
- Sodium isopropyl xanthate
- Reference substance name:
- Proxan-sodium
- EC Number:
- 205-443-5
- EC Name:
- Proxan-sodium
- Cas Number:
- 140-93-2
- Molecular formula:
- C4H8OS2.Na
- IUPAC Name:
- sodium O-isopropyl dithiocarbonate
- Test material form:
- not specified
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
The final conclusion is that the tested sodium O-isopropyl dithiocarbonate (CAS# 140-93-2) is considered to be threatening to humans from this evaluation.
The probability that the prediction is accurate is 80%.
The compound is predicted to be VERY active.
The projected sensitization activity is 55.0 CASE units.
Case units: active = 30 – 80; inactive = 10 – 19; marginal = 20 – 29 .
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
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